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In this review, we summarize the current understanding of the significance of melatonin in macrophage biology and the beneficial effects of melatonin in macrophage\u2010associated diseases. Enzymes associated with synthesis of melatonin, as well as membrane receptors for melatonin, are found in macrophages. Indeed, melatonin influences the phenotype polarization of macrophages. Mechanistically, the roles of melatonin in macrophages are related to several cellular signaling pathways, such as NF\u2010\u03baB, STATs, and NLRP3\/caspase\u20101. Notably, miRNAs (eg, miR\u2010155\/\u201034a\/\u201023a), cellular metabolic pathways (eg, \u03b1\u2010KG, HIF\u20101\u03b1, and ROS), and mitochondrial dynamics and mitophagy are also involved. Thus, melatonin modulates the development and progression of various macrophage\u2010associated diseases, such as cancer and rheumatoid arthritis. This review provides a better understanding about the importance of melatonin in macrophage biology and macrophage\u2010associated diseases.<\/jats:p>","DOI":"10.1111\/jpi.12547","type":"journal-article","created":{"date-parts":[[2018,12,31]],"date-time":"2018-12-31T22:26:12Z","timestamp":1546295172000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":167,"title":["Melatonin in macrophage biology: Current understanding and future perspectives"],"prefix":"10.1111","volume":"66","author":[{"given":"Yaoyao","family":"Xia","sequence":"first","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Animal Nutrition Control, Subtropical Institute of Animal Nutrition and Feed, College of Animal Science South China Agricultural University Guangzhou Guangdong China"},{"name":"University of Chinese Academy of Sciences  Beijing China"},{"name":"Laboratory of Animal Nutrition and Health and Key Laboratory of Agro-Ecology Institute of 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