{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:46:50Z","timestamp":1792104410264,"version":"4.4.0"},"reference-count":52,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["12\u2010TECS\u20100013\u201001"],"award-info":[{"award-number":["12\u2010TECS\u20100013\u201001"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201016\u2010IDEX\u20100005"],"award-info":[{"award-number":["ANR\u201016\u2010IDEX\u20100005"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pineal Research"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Light elicits a range of non\u2010visual responses in humans. Driven predominantly by intrinsically photosensitive retinal ganglion cells (ipRGCs), but also by rods and\/or cones, these responses include melatonin suppression. A sigmoidal relationship has been established between melatonin suppression and light intensity; however, photoreceptoral involvement remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>\n                      In this study, we first modelled the relationships between alpha\u2010opic illuminances and melatonin suppression using an extensive dataset by Brainard and colleagues. Our results show that (a) melatonin suppression is better predicted by melanopic illuminance compared to other alpha\u2010opic illuminances, (b) melatonin suppression is predicted to occur at levels as low as ~1.5 melanopic lux (melanopsin\u2010weighted irradiance 0.2\u00a0\u00b5W\/cm\n                      <jats:sup>2<\/jats:sup>\n                      ), (c) saturation occurs at 305 melanopic lux (melanopsin\u2010weighted irradiance 36.6\u00a0\u00b5W\/cm\n                      <jats:sup>2<\/jats:sup>\n                      ). We then tested this melanopsin\u2010weighted illuminance\u2010response model derived from Brainard and colleagues' data and show that it predicts equally well melatonin suppression data from our laboratory, although obtained using different intensities and exposure duration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Together, our findings suggest that melatonin suppression by monochromatic lights is predominantly driven by melanopsin and that it can be initiated at extremely low melanopic lux levels in experimental conditions. This emphasizes the concern of the non\u2010visual impacts of low light intensities in lighting design and light\u2010emitting devices.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jpi.12562","type":"journal-article","created":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T01:54:25Z","timestamp":1548813265000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":178,"title":["Melatonin suppression is exquisitely sensitive to light and primarily driven by melanopsin in humans"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9396-9448","authenticated-orcid":false,"given":"Abhishek S.","family":"Prayag","sequence":"first","affiliation":[{"name":"Lyon Neuroscience Research Center, Integrative Physiology of the Brain Arousal Systems, Waking team Inserm UMRS 1028, CNRS UMR 5292, Universit\u00e9 Claude Bernard Lyon 1, Universit\u00e9 de Lyon F\u201069000 Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3770-2300","authenticated-orcid":false,"given":"Raymond P.","family":"Najjar","sequence":"additional","affiliation":[{"name":"Department of Visual Neuroscience Singapore Eye Research Institute Singapore"},{"name":"The Ophthalmology &amp; Visual Sciences ACP Duke\u2010NUS Medical School Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6549-799X","authenticated-orcid":false,"given":"Claude","family":"Gronfier","sequence":"additional","affiliation":[{"name":"Lyon Neuroscience Research Center, Integrative Physiology of the Brain Arousal Systems, Waking team Inserm UMRS 1028, CNRS UMR 5292, Universit\u00e9 Claude Bernard Lyon 1, Universit\u00e9 de Lyon F\u201069000 Lyon 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