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Currently, there are no available treatments for NE\u2010AMD. We have developed a NE\u2010AMD model induced by superior cervical ganglionectomy (SCGx) in C57BL\/6J mice, which reproduces the disease hallmarks. Several lines of evidence strongly support the involvement of oxidative stress in NE\u2010AMD\u2010induced retinal pigment epithelium (RPE) and outer retina damage. Melatonin is a proven and safe antioxidant. Our aim was analysing the effect of melatonin in the RPE\/outer retina damage within experimental NE\u2010AMD. The treatment with melatonin starting 48\u00a0h after SCGx, which had no effect on the ubiquitous choriocapillaris widening, protected visual functions and avoided Bruch\u00b4s membrane thickening, RPE melanin content, melanosome number loss, retinoid isomerohydrolase (RPE65)\u2010immunoreactivity decrease, and RPE and hotoreceptor ultrastructural damage induced within experimental NE\u2010AMD exclusively located at the central temporal (but not nasal) region. Melatonin also prevented the increase in outer retina\/RPE oxidative stress markers and a decrease in mitochondrial mass at 6\u00a0weeks post\u2010SCGx. Moreover, when the treatment with melatonin started at 4\u00a0weeks post\u2010SCGx, it restored visual functions and reversed the decrease in RPE melanin content and RPE65\u2010immunoreactivity. These findings suggest that melatonin could become a promising safe therapeutic strategy for NE\u2010AMD.<\/jats:p>","DOI":"10.1111\/jpi.12643","type":"journal-article","created":{"date-parts":[[2020,3,5]],"date-time":"2020-03-05T06:51:30Z","timestamp":1583391090000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Melatonin protects the retina from experimental nonexudative age\u2010related macular degeneration in mice"],"prefix":"10.1111","volume":"68","author":[{"given":"Hern\u00e1n H.","family":"Di\u00e9guez","sequence":"first","affiliation":[{"name":"Laboratory of Retinal Neurochemistry and Experimental Ophthalmology Department of Human Biochemistry School of Medicine\/CEFyBO University of Buenos Aires\/CONICET Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda F.","family":"Gonz\u00e1lez Fleitas","sequence":"additional","affiliation":[{"name":"Laboratory of 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