{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:21:09Z","timestamp":1787494869172,"version":"build-2736575974"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T00:00:00Z","timestamp":1601424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007479","name":"Fondazione Cassa di Risparmio di Padova e Rovigo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011703","name":"Centro studi di Economia e Tecnica dell\u2019Energia Giorgio Levi Cases, Universit\u00e0 degli Studi di Padova","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011703","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pineal Research"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Melatonin is an ancient multi\u2010tasking molecule produced by the pineal gland and by several extrapineal tissues. A variety of activities has been ascribed to this hormone in different physiological and pathological contexts, but little is known about its role in peripheral neuroregeneration. Here, we have exploited two different types of injury to test the capability of melatonin to stimulate regeneration of motor axons: (a) the acute and reversible presynaptic degeneration induced by the spider neurotoxin \u03b1\u2010Latrotoxin and (b) the compression\/transection of the sciatic nerve. We found that in both cases melatonin administration accelerates the process of nerve repair. This pro\u2010regenerative action is MT\n                    <jats:sub>1<\/jats:sub>\n                    \u2010mediated, and at least in part due to a sustained activation of the ERK1\/2 pathway. These findings reveal a receptor\u2010mediated, pro\u2010regenerative action of melatonin in vivo that holds important clinical implications, as it posits melatonin as a safe candidate molecule for the treatment of a number of peripheral neurodegenerative conditions.\n                  <\/jats:p>","DOI":"10.1111\/jpi.12695","type":"journal-article","created":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T03:52:48Z","timestamp":1600314768000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Melatonin promotes regeneration of injured motor axons via MT\n                    <sub>1<\/sub>\n                    receptors"],"prefix":"10.1111","volume":"70","author":[{"given":"Marco","family":"Stazi","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences University of Padua Padua 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