{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T16:48:08Z","timestamp":1788367688900,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T00:00:00Z","timestamp":1661731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pineal Research"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Exposure to fine particulate matter (PM<jats:sub>2.5<\/jats:sub>) was associated with an increased incidence of liver metabolic disease. Melatonin has been shown to prevent liver glucolipid metabolism disorders. However, whether melatonin could rescue PM<jats:sub>2.5<\/jats:sub>\u2010induced liver metabolic abnormalities remains uncertain. This study was to evaluate the mitigating effect of melatonin on PM<jats:sub>2.5<\/jats:sub>\u2010accelerated hepatic glucose metabolism imbalance in vivo and in vitro. Schiff periodic acid shiff\u00a0staining and other results showed that PM<jats:sub>2.5<\/jats:sub> led to a decrease in hepatic glycogen reserve and an increase in glucose content, which was effectively alleviated by melatonin. Targeted lipidomics is used to identify lipid biomarkers associated with this process, including glycerolipids, glycerophospholipids, and sphingolipids. In addition, gene microarray and quantitative polymerase chain reaction analysis of ApoE<jats:sup>\u2212\/\u2212<\/jats:sup> mice liver suggested that PM<jats:sub>2.5<\/jats:sub> activated the miR\u2010200a\u20103p and inhibited DNAJB9, and the targeting relationship was verified by luciferase reports for the first time. Further investigation demonstrated that DNAJB9 might motivate endoplasmic reticulum\u00a0(ER) stress by regulating Ca<jats:sup>2+<\/jats:sup> homeostasis, thus altering the protein expression of GSK3B, FOXO1, and PCK2. Meanwhile, melatonin effectively inhibited miR\u2010200a\u20103p and glucose metabolism disorder. Knockout of miR\u2010200a\u20103p in L02 cells revealed that miR\u2010200a\u20103p is indispensable in the damage of PM<jats:sub>2.5<\/jats:sub> and the therapeutic effect of melatonin. In summary, melatonin alleviated PM<jats:sub>2.5<\/jats:sub>\u2010induced liver metabolic dysregulation by regulating ER stress via miR\u2010200a\u20103p\/DNAJB9 signaling pathway. Our data provide a prospective targeted therapy for air pollution\u2010related liver metabolism disorders.<\/jats:p>","DOI":"10.1111\/jpi.12823","type":"journal-article","created":{"date-parts":[[2022,8,20]],"date-time":"2022-08-20T04:38:50Z","timestamp":1660970330000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Melatonin alleviates PM<sub>2.5<\/sub>\u2010induced glucose metabolism disorder and lipidome alteration by regulating endoplasmic reticulum stress"],"prefix":"10.1111","volume":"73","author":[{"given":"Zhou","family":"Du","sequence":"first","affiliation":[{"name":"Department of Toxicology and Sanitary Chemistry, School of Public Health Capital Medical University Beijing People's Republic of China"},{"name":"Beijing Key Laboratory of Environmental Toxicology Capital Medical University Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Toxicology and Sanitary Chemistry, School of Public Health Capital Medical University Beijing People's Republic of China"},{"name":"Beijing Key Laboratory of Environmental Toxicology Capital Medical University Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisen","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Toxicology and Sanitary Chemistry, School of Public Health Capital Medical University Beijing People's Republic of China"},{"name":"Beijing Key Laboratory of Environmental Toxicology Capital Medical University Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Toxicology and Sanitary Chemistry, School of Public Health Capital Medical University Beijing People's Republic of China"},{"name":"Beijing Key Laboratory of Environmental Toxicology Capital Medical University Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengqi","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Toxicology and Sanitary Chemistry, School of Public Health Capital Medical University Beijing People's Republic of China"},{"name":"Beijing Key Laboratory of Environmental Toxicology Capital Medical University Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Toxicology and Sanitary Chemistry, School of Public Health Capital Medical University Beijing People's Republic of China"},{"name":"Beijing Key Laboratory of Environmental Toxicology Capital Medical University Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junchao","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Toxicology and Sanitary Chemistry, School of Public Health Capital Medical University Beijing People's Republic of China"},{"name":"Beijing Key Laboratory of Environmental Toxicology Capital Medical University Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,29]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-04190-y"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssensors.0c01524"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2021.118135"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1818134116"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwx127"},{"key":"e_1_2_11_7_1","doi-asserted-by":"crossref","unstructured":"LinYC ShihHS LaiCY.Long\u2010term nonlinear relationship between PM(2.5) and ten leading causes of death.Environ Geochem Health. 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