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Prior studies have found that light disruption after myocardial infarction (MI) exacerbates cardiac remodeling, and the brain\u2010heart sympathetic nervous system may be one of the key mechanisms. However, how to improve light\u2010disrupted cardiac remodeling remains unclear. Melatonin is an indoleamine secreted by the pineal gland and controlled by endogenous circadian oscillators within the suprachiasmatic nucleus, which is closely associated with light\/dark cycle. This study aimed to explore whether melatonin could improve light\u2010disrupted cardiac remodeling and modulate the brain\u2010heart sympathetic nervous system. Our study revealed that light disruption reduced serum melatonin levels, aggravated cardiac sympathetic remodeling, caused overactivation of the brain\u2010heart sympathetic nervous system, exacerbated cardiac dysfunction, and increased cardiac fibrosis after MI, while melatonin treatment improved light disruption\u2010exacerbated cardiac remodeling and brain\u2010heart sympathetic hyperactivation after MI. Furthermore, RNA\u2010Seq results revealed the significant changes at the cardiac transcription level. In conclusion, melatonin may be a potential therapy for light\u2010disrupted cardiac remodeling.<\/jats:p>","DOI":"10.1111\/jpi.12829","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T05:23:13Z","timestamp":1661750593000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Melatonin improves cardiac remodeling and brain\u2013heart sympathetic hyperactivation aggravated by light disruption after myocardial infarction"],"prefix":"10.1111","volume":"73","author":[{"given":"Liying","family":"Jiao","sequence":"first","affiliation":[{"name":"Department of Cardiology Renmin Hospital of Wuhan University  Wuhan China"},{"name":"Cardiac Autonomic Nervous System Research Center of Wuhan University  Wuhan China"},{"name":"Cardiovascular Research Institute Wuhan University  Wuhan China"},{"name":"Hubei Key Laboratory of Cardiology  Wuhan 430060 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