{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T05:08:32Z","timestamp":1789189712055,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T00:00:00Z","timestamp":1669248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pineal Research"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this double\u2010blind, placebo\u2010controlled, randomized study was to investigate whether topical melatonin administered during radiation therapy could increase the quality of life in patients with primary breast cancer. Patients were followed from the first radiation fraction until 3 weeks after the last. The patients applied 1\u2009g of cream to the irradiated area of the skin twice daily, consisting of either 25\u2009mg\/g melatonin and 150\u2009mg\/g dimethyl sulfoxide, or a placebo cream. Outcomes were the European Organisation for Research and Treatment of Cancer's quality\u2010of\u2010life questionnaires for breast cancer (QLQ\u2010C30 and QLQ\u2010BR23) on the last day of radiation therapy. As a secondary outcome, we evaluated the breast symptom (BS) scores over the entire duration of the trial in a repeated measures linear model. We included 65 patients and had 17 drop\u2010outs, thus totaling 26 and 22 patients in the melatonin and placebo groups, respectively. BS scores on the last day of radiation did not differ between groups (<jats:italic>p<\/jats:italic>\u2009=\u2009.333). However, the linear model analyzing BS for the entire duration showed that melatonin significantly decreased the symptoms (<jats:italic>p<\/jats:italic>\u2009=\u2009.001).\u00a0There was no difference in the BS score on the last day of radiation, however, we found that the patients in the melatonin group had significantly lower BS scores over the entire duration of the trial.<\/jats:p>","DOI":"10.1111\/jpi.12840","type":"journal-article","created":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T04:54:25Z","timestamp":1668660865000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Quality\u2010of\u2010life outcomes following topical melatonin application against acute radiation dermatitis in patients with early breast cancer: A double\u2010blind, randomized, placebo\u2010controlled trial"],"prefix":"10.1111","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8533-8777","authenticated-orcid":false,"given":"Dennis","family":"Zetner","sequence":"first","affiliation":[{"name":"Department of Surgery, Herlev Hospital University of Copenhagen  Herlev Denmark"},{"name":"Department of Radiology, Rigshospitalet University of Copenhagen  Copenhagen \u00d8 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Kamby","sequence":"additional","affiliation":[{"name":"Department of Oncology, Rigshospitalet University of Copenhagen  Copenhagen \u00d8 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seng\u00fcl","family":"G\u00fclen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Herlev Hospital University of Copenhagen  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Christophersen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Herlev Hospital University of Copenhagen  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilie B.","family":"Paulsen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Herlev Hospital University of Copenhagen  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Piga","sequence":"additional","affiliation":[{"name":"Department of Surgery, Herlev Hospital University of Copenhagen  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bodil","family":"Hoffmeyer","sequence":"additional","affiliation":[{"name":"Department of Surgery, Herlev Hospital University of Copenhagen  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faisal","family":"Mahmood","sequence":"additional","affiliation":[{"name":"Department of Oncology, Odense University Hospital University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"Department of Surgery, Herlev Hospital University of Copenhagen  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.08.054"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctarc.2021.100403"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04751.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejon.2018.01.008"},{"key":"e_1_2_8_6_1","first-page":"5343","article-title":"Topical management of acute radiation dermatitis in breast cancer patients: a systematic review and meta\u2010analysis","volume":"37","author":"Haruna F","year":"2017","journal-title":"Anticancer Res"},{"key":"e_1_2_8_7_1","first-page":"188","article-title":"Melatonin for prevention of breast radiation dermatitis: a phase II, prospective, double\u2010blind randomized trial","volume":"18","author":"Ben\u2010David MA","year":"2016","journal-title":"Israel Med\u00a0Assoc\u00a0J"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13265"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2017.0081"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-021-02586-w"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.32794\/mr11250010"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c332"},{"key":"e_1_2_8_13_1","unstructured":"Danish Breast Cancer Group. 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