{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:14:31Z","timestamp":1790957671725,"version":"4.1.0"},"reference-count":65,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T00:00:00Z","timestamp":1674432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pineal Research"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Melatonin has been proven to have antiarrhythmic potential; however, several studies have recently challenged this view. Herein, using a mouse model of obesity\u2010induced atrial fibrillation (AF), we tentatively explored whether exogenous melatonin supplementation could increase AF susceptibility in the context of obesity. We observed that an 8\u2010week drinking administration of melatonin (60\u2009\u00b5g\/ml in water) induced a greater susceptibility to AF in obese mice, although obesity\u2010induced structural remodeling was alleviated. An investigation of systemic insulin sensitivity showed that melatonin treatment improved insulin sensitivity in obese mice, whereas it inhibited glucose\u2010stimulated insulin secretion. Notably, melatonin treatment inhibited protein kinase B (Akt) signaling in the atria of obese mice and palmitate\u2010treated neonatal rat cardiomyocytes, thereby providing an AF substrate. Melatonin increased lipid stress in obesity, as evidenced by elevated lipid accumulation and lipolysis\u2010related gene expression, thus contributing to the impairment in atrial Akt signaling. Taken together, our results demonstrated that melatonin could increase AF susceptibility in obesity, probably due to increased lipid stress and resultant impairment of atrial Akt signaling. Our findings suggest that special precautions should be taken when administering melatonin to obese subjects.<\/jats:p>","DOI":"10.1111\/jpi.12851","type":"journal-article","created":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T22:44:10Z","timestamp":1673649850000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Melatonin increases susceptibility to atrial fibrillation in obesity via Akt signaling impairment in response to lipid overload"],"prefix":"10.1111","volume":"74","author":[{"given":"Xinghua","family":"Qin","sequence":"first","affiliation":[{"name":"Xi'an Key Laboratory of Special Medicine and Health Engineering, School of Life Sciences Northwestern Polytechnical University  Beilin District Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuping","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Second Affiliated Hospital of Xi'an Jiaotong University  Xincheng District Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiali","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Second Affiliated Hospital of Xi'an Jiaotong University  Xincheng District Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binghua","family":"Liu","sequence":"additional","affiliation":[{"name":"Xi'an Key Laboratory of Special Medicine and Health Engineering, School of Life Sciences Northwestern Polytechnical University  Beilin District Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Second Affiliated Hospital of Xi'an Jiaotong University  Xincheng District Xi'an Shaanxi 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