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The light\u2010sensitive pineal gland of fish, birds, and amphibians is evolutionarily related to the eye but lacks a pigmented epithelium. Thus, it is unclear how these functions are performed. Here, we ask whether a subpopulation of zebrafish pineal cells, which express glial markers and visual cycle genes, is involved in maintaining photoreceptors. Selective ablation of these cells leads to a loss of pineal photoreceptors. Moreover, these cells internalize exorhodopsin that is secreted by pineal rod\u2010like photoreceptors, and in turn release CD63\u2010positive extracellular vesicles (EVs) that are taken up by <jats:italic>pdgfrb<\/jats:italic>\u2010positive phagocytic cells in the forebrain meninges. These results identify a subpopulation of glial cells that is critical for pineal photoreceptor survival and indicate the existence of cells in the forebrain meninges that receive EVs released by these pineal cells and potentially function in waste disposal.<\/jats:p>","DOI":"10.1111\/jpi.12854","type":"journal-article","created":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T13:40:29Z","timestamp":1674567629000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Glial cells expressing visual cycle genes are vital for photoreceptor survival in the zebrafish pineal gland"],"prefix":"10.1111","volume":"74","author":[{"given":"Yotam","family":"Elazary","sequence":"first","affiliation":[{"name":"School of Neurobiology, Biochemistry and Biophysics, The George S. 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