{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T16:19:15Z","timestamp":1780589955996,"version":"3.54.1"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T00:00:00Z","timestamp":1688947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pineal Research"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Female night\u2010workers get exposed to frequent light shifts, hence have altered circadian rhythm and are at high risk of endometrial cancer; the underlying mechanism however is still not clear. We, therefore examined the effect of long light exposure (16L:8D, LD1) and regular shift (8\u2009h) in long nighttime (LD2) on endometrial changes of female golden hamsters. Morphometric analysis, scanning electron microscopy imaging, alcian blue staining, and cytological nuclear atypia of endometrial stromal cells confirmed the incidence of endometrial adenocarcinoma in LD2 exposed hamsters. But, less severe pathomorphological alterations were noted in uterus of LD1 exposed hamsters. Altered <jats:italic>Aanat<\/jats:italic> and <jats:italic>Bmal1<\/jats:italic> mRNA, melatonin rhythm, downregulation of important marker gene of adenocarcinoma like Akt, 14\u20103\u20103, and PR protein expression and upregulation PKC\u03b1, pAkt\u2010S473 and vascular epithelial growth factor (VEGF) were observed in LD2 exposed hamsters suggesting the endometrial adenocarcinoma. Further, our western blot analysis supported the immunohistochemical localization of PR, PKC\u03b1, and VEGF in uterine tissues along low progesterone. Overall, our data indicates that light shift and long light exposure potentially induced endometrioid adenocarcinoma via activation of PKC\u2010\u03b1\/Akt pathway in female hamsters. Therefore, duration of light is essential for female normal uterine function.<\/jats:p>","DOI":"10.1111\/jpi.12894","type":"journal-article","created":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T02:32:31Z","timestamp":1687833151000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Shift and longtime light induces endometrioid adenocarcinoma via activation of PKC\u2010\u03b1\/Akt pathway in female golden hamster: Involvement of altered <i>Aanat<\/i> and <i>Bmal1<\/i> rhythm"],"prefix":"10.1111","volume":"75","author":[{"given":"Megha","family":"Das","sequence":"first","affiliation":[{"name":"Department of Zoology, Institute of Science Banaras Hindu University Varanasi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandana","family":"Haldar","sequence":"additional","affiliation":[{"name":"Department of Zoology, Institute of Science Banaras Hindu University Varanasi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2724-7284","authenticated-orcid":false,"given":"Sanjeev Kumar","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Zoology, Institute of Science Banaras Hindu University Varanasi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2014.0133"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genet-102209-163432"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-073109-130051"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2011.06.042"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.21767\/2254-6081.1000133"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2012.658792"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2012.01.001"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2017.02.008"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.2009.046797"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-008-0729-5"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2005.05.010"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/95.11.825"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwj232"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-2485"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a114569"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2004.00186.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S203144"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.20198"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1756"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2022.112508"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2016.262"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep31846"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/19396368.2017.1408715"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2020.125998"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/cyt.12149"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2016.12.002"},{"key":"e_1_2_9_29_1","doi-asserted-by":"crossref","unstructured":"MolcanL. 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