{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:16:08Z","timestamp":1789996568965,"version":"4.0.1"},"reference-count":88,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T00:00:00Z","timestamp":1700611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pineal Research"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Immune\u2010pineal axis activation is part of the assembly of immune responses. Proinflammatory cytokines inhibit the pineal synthesis of melatonin while inducing it in macrophages by mechanisms dependent on nuclear factor\u2010\u03baB (NF\u2010\u03baB) activation. Cytokines activating the Janus kinase\/signal transducer and activator of transcription (STAT) pathways, such as interferon\u2010gamma (IFN\u2010\u03b3) and interleukin\u201010 (IL\u201010), modulate melatonin synthesis in the pineal, bone marrow (BM), and spleen. The stimulatory effect of IFN\u2010\u03b3 upon the pineal gland depends on STAT1\/NF\u2010\u03baB interaction, but the mechanisms controlling IL\u201010 effects on melatonin synthesis remain unclear. Here, we evaluated the role of STAT3 and NF\u2010\u03baB activation by IL\u201010 upon the melatonin synthesis of rats' pineal gland, BM, spleen, and peritoneal cells. The results show that IL\u201010\u2010induced interaction of (p)STAT3 with specific NF\u2010\u03baB dimmers leads to different cell effects. IL\u201010 increases the pineal's acetylserotonin O\u2010methyltransferase (ASMT), <jats:italic>N<\/jats:italic>\u2010acetylserotonin, and melatonin content via nuclear translocation of NF\u2010\u03baB\/STAT3. In BM, the nuclear translocation of STAT3\/p65\u2010NF\u2010\u03baB complexes increases ASMT expression and melatonin content. Increased pSTAT3\/p65\u2010NF\u2010\u03baB nuclear translocation in the spleen enhances phosphorylated serotonin <jats:italic>N<\/jats:italic>\u2010acetyltransferase ((p)SNAT) expression and melatonin content. Conversely, in peritoneal cells, IL\u201010 leads to NF\u2010\u03baB p50\/p50 inhibitory dimmer nuclear translocation, decreasing (p)SNAT expression and melatonin content. In conclusion, IL\u201010's effects on melatonin production depend on the NF\u2010\u03baB subunits interacting with (p)STAT3. Thus, variations of IL\u201010 levels and downstream pathways during immune responses might be critical regulatory factors adjusting pineal and extra\u2010pineal synthesis of melatonin.<\/jats:p>","DOI":"10.1111\/jpi.12923","type":"journal-article","created":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T23:52:52Z","timestamp":1700783572000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["IL\u201010\u2010induced STAT3\/NF\u2010\u03baB crosstalk modulates pineal and extra\u2010pineal melatonin synthesis"],"prefix":"10.1111","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8055-0085","authenticated-orcid":false,"given":"Marlina O.","family":"C\u00f3rdoba\u2010Moreno","sequence":"first","affiliation":[{"name":"Department of Physiology University of S\u00e3o Paulo S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela Christine","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Physiology University of S\u00e3o Paulo S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra M.","family":"Muxel","sequence":"additional","affiliation":[{"name":"Department of Physiology University of S\u00e3o Paulo S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4613-187X","authenticated-orcid":false,"given":"D\u00e9bora","family":"dos Santos\u2010Silva","sequence":"additional","affiliation":[{"name":"Department of Physiology University of S\u00e3o Paulo S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline L.","family":"Quiles","sequence":"additional","affiliation":[{"name":"Department of Physiology University of S\u00e3o Paulo S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kassiano D. 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