{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T14:59:45Z","timestamp":1784300385810,"version":"3.55.0"},"reference-count":57,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T00:00:00Z","timestamp":1720396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100013058","name":"Jiangsu Provincial Key Research and Development Program","doi-asserted-by":"publisher","award":["D18007."],"award-info":[{"award-number":["D18007."]}],"id":[{"id":"10.13039\/501100013058","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pineal Research"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Colistin is renowned as a last\u2010resort antibiotic due to the emergence of multidrug\u2010resistant pathogens. However, its potential toxicity significantly hampers its clinical utilization. Melatonin, chemically known as <jats:italic>N<\/jats:italic>\u2010acetyl\u20105\u2010hydroxytryptamine, is an endogenous hormone produced by the pineal gland and possesses diverse biological functions. However, the protective role of melatonin in alleviating antibiotic\u2010induced intestinal inflammation remains unknown. Herein, we reveal that colistin stimulation markedly elevates intestinal inflammatory levels and compromises the gut barrier. In contrast, pretreatment with melatonin safeguards mice against intestinal inflammation and mucosal damage. Microbial diversity analysis indicates that melatonin supplementation prevents a reduction in the abundance of <jats:italic>Erysipelotrichales<\/jats:italic> and <jats:italic>Bifidobacteriales<\/jats:italic>, as well as an increase in <jats:italic>Desulfovibrionales<\/jats:italic> abundance, following colistin exposure. Remarkably, short\u2010chain fatty acids (SCFAs) analysis shows that propanoic acid contributes to the protective effect of melatonin on colistin\u2010induced intestinal inflammation. Furthermore, the protection effects of melatonin and propanoic acid on LPS\u2010induced cellular inflammation in RAW 264.7 cells are confirmed. Mechanistic investigations suggest that intervention with melatonin and propanoic acid can repress the activation of the TLR4 signal and its downstream NF\u2010\u03baB and MAPK signaling pathways, thereby mitigating the toxic effects of colistin. Our work highlights the unappreciated role of melatonin in preventing the potential detrimental effects of colistin on intestinal health and suggests a combined therapeutic strategy to effectively manage intestinal infectious diseases.<\/jats:p>","DOI":"10.1111\/jpi.12989","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T06:21:04Z","timestamp":1720506064000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Melatonin Protects Against Colistin\u2010Induced Intestinal Inflammation and Microbiota Dysbiosis"],"prefix":"10.1111","volume":"76","author":[{"given":"Yuqian","family":"Jia","sequence":"first","affiliation":[{"name":"Jiangsu Co\u2010Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, College of Veterinary Medicine Yangzhou University Yangzhou 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