{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T04:06:54Z","timestamp":1789099614560,"version":"build-2803163510"},"reference-count":124,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T00:00:00Z","timestamp":1723420800000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pineal Research"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In mammals, seasonal opportunities and challenges are anticipated through programmed changes in physiology and behavior. Appropriate anticipatory timing depends on synchronization to the external solar year, achieved through the use of day length (photoperiod) as a synchronizing signal. In mammals, nocturnal production of melatonin by the pineal gland is the key hormonal mediator of photoperiodic change, exerting its effects via the hypothalamopituitary axis. In this review\/perspective, we consider the key developments during the history of research into the seasonal synchronizer effect of melatonin, highlighting the role that the\n                    <jats:italic>pars tuberalis<\/jats:italic>\n                    \u2013tanycyte module plays in this process. We go on to consider downstream pathways, which include discrete hypothalamic neuronal populations. Neurons that express the neuropeptides kisspeptin and (Arg)(Phe)\u2013related peptide\u20103 (RFRP\u20103) govern seasonal reproductive function while neurons that express somatostatin may be involved in seasonal metabolic adaptations. Finally, we identify several outstanding questions, which need to be addressed to provide a much thorough understanding of the deep impact of melatonin upon seasonal synchronization.\n                  <\/jats:p>","DOI":"10.1111\/jpi.12996","type":"journal-article","created":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T05:49:01Z","timestamp":1723441741000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Melatonin and Seasonal Synchrony in Mammals"],"prefix":"10.1111","volume":"76","author":[{"given":"David G.","family":"Hazlerigg","sequence":"first","affiliation":[{"name":"Department of Arctic and Marine Biology, Arctic Chronobiology and Physiology Research Group, Arctic Seasonal Timekeeping Initiative (ASTI) UiT\u2010The Arctic University of Norway  Troms\u00f8 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