{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T23:45:31Z","timestamp":1792280731094,"version":"4.4.0"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T00:00:00Z","timestamp":1722816000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pineal Research"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Limited research has reported the association between <jats:italic>MTNR1B<\/jats:italic> gene polymorphisms and ischemic stroke (IS), and there is insufficient evidence on whether adopting a healthy lifestyle can mitigate genetic risks in this context. This study aimed to investigate the associations between <jats:italic>MTNR1B<\/jats:italic> gene variants (rs10830963 and rs1387153) and IS, examining the potential effect of gene\u2013lifestyle interactions on IS risk. Conducted in northern China, this family\u2010based cohort study involved 5116 initially IS\u2010free subjects. Genotype data for rs10830963 and rs1387153 in <jats:italic>MTNR1B<\/jats:italic> were collected. Eight modifiable lifestyle factors, including body mass index (BMI), smoking, alcohol consumption, dietary habits, physical activity, sedentary time, sleep duration, and chronotype, were considered in calculating healthy lifestyle scores. Multilevel Cox models were used to examine the associations between <jats:italic>MTNR1B<\/jats:italic> variants and IS. Participants carrying the rs10830963\u2010G and rs1387153\u2010T alleles exhibited an elevated IS risk. Each additional rs10830963\u2010G allele and rs1387153\u2010T allele increased the IS risk by 36% (HR\u2009=\u20091.36, 95%\u00a0CI, 1.12\u20131.65) and 32% (HR\u2009=\u20091.32, 95%\u00a0CI, 1.09\u20131.60), respectively. Participants were stratified into low, medium, and high healthy lifestyle score groups (1537, 2188, and 1391 participants, respectively). Genetic\u2013lifestyle interactions were observed for rs10830963 and rs1387153 (<jats:italic>p<\/jats:italic> for interaction\u2009&lt;\u20090.001). Notably, as the healthy lifestyle score increased, the effect of <jats:italic>MTNR1B<\/jats:italic> gene variants on IS risk diminished (<jats:italic>p<\/jats:italic> for trend\u2009&lt;\u20090.001). This study underscores the association between the <jats:italic>MTNR1B<\/jats:italic> gene and IS, emphasizing that adherence to a healthy lifestyle can mitigate the genetic predisposition to IS.<\/jats:p>","DOI":"10.1111\/jpi.13000","type":"journal-article","created":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T10:25:00Z","timestamp":1722853500000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Healthy Lifestyles Modify the Association of Melatonin Receptor 1B Gene and Ischemic Stroke: A Family\u2010Based Cohort Study in Northern China"],"prefix":"10.1111","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2973-7711","authenticated-orcid":false,"given":"Huangda","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health, Peking University Beijing 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Major Diseases (Peking University) Ministry of Education Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqun","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health, Peking University Beijing China"},{"name":"Key Laboratory of Epidemiology of Major Diseases (Peking University) Ministry of Education Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueying","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health, Peking University Beijing China"},{"name":"Key Laboratory of Epidemiology of Major Diseases (Peking University) Ministry of Education Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health, Peking University 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