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This study is aimed to determine the evidence of melatonin in rheumatoid arthritis (RA)\u2010related pathological muscle atrophy. We used initially bioinformatics results to show that melatonin regulated significantly the correlation between pro\u2010inflammation and myogenesis in RA synovial fibroblasts (RASF) and myoblasts. The conditioned medium (CM) from melatonin\u2010treated RASF was incubated in myoblasts with growth medium and differentiated medium to investigate the markers of pro\u2010inflammation, atrophy, and myogenesis. We found that melatonin regulated RASF CM\u2010induced pathological muscle pro\u2010inflammation and atrophy in myoblasts and differentiated myocytes through NF\u2010\u03baB signaling pathways. We also showed for the first time that miR\u201030c\u20101\u20103p is negatively regulated by three inflammatory cytokines in human RASF, which is associated with murine\u2010differentiated myocytes. Importantly, oral administration with melatonin in a collagen\u2010induced arthritis (CIA) mouse model also significantly improved arthritic swelling, hind limb grip strength as well as pathological muscle atrophy. In conclusion, our study is the first to demonstrate not only the underlying mechanism whereby melatonin decreases pro\u2010inflammation in RA\u2010induced pathological muscle atrophy but also increases myogenesis in myoblasts and differentiated myocytes.<\/jats:p>","DOI":"10.1111\/jpi.13009","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T13:00:50Z","timestamp":1727182850000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Melatonin Regulates Rheumatoid Synovial Fibroblasts\u2010Related Inflammation: Implications for Pathological Skeletal Muscle Treatment"],"prefix":"10.1111","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9336-4668","authenticated-orcid":false,"given":"Chen\u2010Ming","family":"Su","sequence":"first","affiliation":[{"name":"Department of Sports Medicine China Medical University Taichung City 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