{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:00:02Z","timestamp":1787166002633,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T00:00:00Z","timestamp":1734912000000},"content-version":"vor","delay-in-days":52,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pineal Research"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Located dorsally underneath a thin translucent skull in many teleosts, the pineal gland is a photoreceptive organ known as a key element of the circadian clock system. Nevertheless, the presence of additional routes of photoreception presents a challenge in determining its specific roles in regulating photic\u2010related behavior. Here, we show the importance of the pineal gland in mediating a prolonged motor response of zebrafish larvae to sudden darkness, both as a photodetector and as a circadian pacemaker. This was evident by a reduced motor response of Bsx\u2010deficient larvae, lacking a pineal gland, to sudden darkness. Moreover, the typical daily rhythm of the intensity of this response was lost in the pineal\u2010less larvae. In contrast, motor response to a sudden increase in illumination was unaffected. Furthermore, we show that the pineal\u2010mediated behavioral response to darkness requires two elements: the photoreceptor cells and the projecting neurons. Dark response was impaired in larvae whose pineal photoreceptor cells were genetically ablated and in larvae whose pineal projecting neurons had undergone laser\u2010axotomy. This study thus establishes the pineal gland as a mediator of dark\u2010dependent behavior and reveals underlying cellular components involved in transducing information about darkness to the brain.<\/jats:p>","DOI":"10.1111\/jpi.70021","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T05:02:57Z","timestamp":1734930177000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Zebrafish Dark\u2010Dependent Behavior Requires Phototransduction by the Pineal Gland"],"prefix":"10.1111","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6270-3188","authenticated-orcid":false,"given":"Yair","family":"Wexler","sequence":"first","affiliation":[{"name":"School of Neurobiology, Biochemistry and Biophysics, The George S. Wise Faculty of Life Sciences Tel\u2010Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dengfeng","family":"Huang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Neuroscience CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Neuroscience, Chinese Academy of Sciences Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adar","family":"Medvetzky","sequence":"additional","affiliation":[{"name":"School of Neurobiology, Biochemistry and Biophysics, The George S. Wise Faculty of Life Sciences Tel\u2010Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Armbruster","sequence":"additional","affiliation":[{"name":"Developmental Biology, Institute Biology I, Faculty of Biology University of Freiburg Freiburg Germany"},{"name":"CIBSS and BIOSS\u2014Centres for Biological Signalling Studies University of Freiburg Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Driever","sequence":"additional","affiliation":[{"name":"Developmental Biology, Institute Biology I, Faculty of Biology University of Freiburg Freiburg Germany"},{"name":"CIBSS and BIOSS\u2014Centres for Biological Signalling Studies University of Freiburg Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Neuroscience CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Neuroscience, Chinese Academy of Sciences Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6054-4128","authenticated-orcid":false,"given":"Yoav","family":"Gothilf","sequence":"additional","affiliation":[{"name":"School of Neurobiology, Biochemistry and Biophysics, The George S. 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