{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T21:16:58Z","timestamp":1793740618168,"version":"4.6.1"},"reference-count":75,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pineal Research"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Sarcopenia, a condition associated with aging, involves progressive loss of muscle mass, strength, and function, leading to impaired mobility, health, and increased mortality. The underlying mechanisms remain unclear, which limits the development of effective therapeutic interventions. Emerging evidence implicates chronodisruption as a key contributor to sarcopenia, emphasizing the role of\n                    <jats:italic>Bmal1<\/jats:italic>\n                    , a circadian clock gene critical for muscle integrity and mitochondrial function. In a skeletal muscle\u2010specific and inducible\n                    <jats:italic>Bmal1<\/jats:italic>\n                    knockout model (iMS\u2010\n                    <jats:italic>Bmal1<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    ), we observed hallmark features of sarcopenia, including disrupted rhythms, impaired muscle function, and mitochondrial dysfunction. Exercise and melatonin treatment reversed these deficits independently of\n                    <jats:italic>Bmal1<\/jats:italic>\n                    . Building on these findings, the present study elucidates several mechanisms underlying these changes and the pathways by which melatonin and exercise exert their beneficial effects. Our findings indicate that iMS\u2010\n                    <jats:italic>Bmal1<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice exhibit reduced expression of satellite cell and muscle regulatory factors, indicating impaired muscle regeneration. While mitochondrial respiration remained unchanged, notable alterations in mitochondrial dynamics disrupted mitochondria in skeletal muscle. In addition, these mice showed alterations in muscle energy metabolism, compromised antioxidant defense, and inflammatory response. Remarkably, exercise and\/or melatonin successfully mitigated these deficits, restoring muscle health in\n                    <jats:italic>Bmal1<\/jats:italic>\n                    \u2010deficient mice. These findings position exercise and melatonin as promising therapeutic candidates for combating sarcopenia and emphasize the need to elucidate the molecular pathways underlying their protective effects.\n                  <\/jats:p>","DOI":"10.1111\/jpi.70049","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T03:13:46Z","timestamp":1744859626000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Melatonin and Exercise Restore Myogenesis and Mitochondrial Dynamics Deficits Associated With Sarcopenia in iMS\u2010\n                    <i>Bmal1<\/i>\n                    <sup>\u2212\/\u2212<\/sup>\n                    Mice"],"prefix":"10.1111","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5855-0449","authenticated-orcid":false,"given":"Yolanda","family":"Ram\u00edrez\u2010Casas","sequence":"first","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica, Facultad de Medicina, Departamento de Fisiolog\u00eda, Instituto de Biotecnolog\u00eda, Parque Tecnol\u00f3gico de Ciencias de la Salud Universidad de Granada Granada Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria (Ibs. 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