{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T01:09:24Z","timestamp":1789175364745,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T00:00:00Z","timestamp":1747094400000},"content-version":"vor","delay-in-days":42,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pineal Research"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Core body temperature (CBT) is a crucial marker of circadian synchrony, reflecting behavioral, metabolic, and environmental adaptations. Disruptions to CBT rhythms, as seen in shift workers or jetlag, indicate desynchronization and can lead to significant health consequences. Exercise is a potent non\u2010photic zeitgeber that may help align circadian rhythms with external cues, but its role in re\u2010entrainment following abrupt phase shifts remains unclear. This study investigated whether voluntary exercise accelerates the re\u2010entrainment of CBT and metabolic rhythms in mice subjected to a 12\u2010h light\u2010dark cycle inversion (LDI). Fifteen C57BL\/6\u2009J mice underwent LDI and were divided into two groups. Mice in the control (CTRL) group remained sedentary throughout the experiment while mice in the other group were provided running wheels for 2 weeks after LDI. CBT was continuously monitored using implanted telemetric capsules and metabolic parameters were assessed before and 2 weeks after LDI. Mice that had access to running wheels (RW mice) initially displayed a greater disruption of CBT rhythmicity following LDI, suggesting unstructured physical activity may temporarily exacerbate misalignment, acting as a conflicting signal. Despite this, exercise accelerated recovery, as the phase of the CBT rhythm in RW mice re\u2010aligned to the new light\u2010dark cycle faster than that of the CTRL mice did. The phase of VO\u2082 rhythms in RW mice also showed trends toward faster realignment. These findings highlight the dual role of exercise as a zeitgeber, capable of both disrupting and accelerating circadian realignment depending on timing. Voluntary exercise may thus serve as an effective intervention to restore circadian synchrony and metabolic homeostasis in individuals experiencing circadian disruptions.<\/jats:p>","DOI":"10.1111\/jpi.70057","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T06:37:04Z","timestamp":1747118224000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Exercise as a Synchronizer: Effects on Circadian Re\u2010Entrainment of Core Body Temperature and Metabolism Following Light\u2013Dark Cycle Inversion in Mice"],"prefix":"10.1111","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0448-6223","authenticated-orcid":false,"given":"Andrea Michele","family":"Ciorciari","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences for Health University of Milan Milan Italy"},{"name":"Department of Molecular and Cellular Biology Scripps Research La Jolla CA 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