{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T19:51:44Z","timestamp":1781725904380,"version":"3.54.5"},"reference-count":63,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pineal Research"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Aging is associated with increased susceptibility to bacterial infections, particularly multidrug\u2010resistant (MDR) strains, which often result in antibiotic treatment failure and high mortality rates in the elderly. However, effective preventive and therapeutic strategies remain limited. Herein, we showed that aged mice exhibited higher susceptibility to colistin\u2010resistant\n                    <jats:italic>Salmonella enterica<\/jats:italic>\n                    serotype Typhimurium and methicillin\u2010resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    compared to young mice. Notably, pre\u2010supplementation with melatonin, a hormone markedly reduced in the aging gut, effectively restricted MDR bacterial infections in aged mice by enhancing microbial colonization resistance. Mechanistically, melatonin\u2010induced alterations in the gut microbiota, particularly the enrichment of butyrate\u2010producing bacteria including\n                    <jats:italic>Faecalibaculum<\/jats:italic>\n                    ,\n                    <jats:italic>Muribaculaceae<\/jats:italic>\n                    , and\n                    <jats:italic>Ruminococcus<\/jats:italic>\n                    , played a pivotal role in enhancing resistance to pathogenic bacteria. Elevated gut butyrate levels following melatonin pre\u2010supplementation not only preserved intestinal barrier integrity and mitigated inflammaging, but also directly inhibited pathogenic bacterial growth by disrupting intracellular pH homeostasis, leading to proton motive force dissipation and metabolic disturbances. These findings underscore melatonin and its metabolite, butyrate, as promising candidates for the prevention of MDR bacterial infections in the aging population.\n                  <\/jats:p>","DOI":"10.1111\/jpi.70087","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T05:46:29Z","timestamp":1759988789000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Melatonin Confers Protection Against Multidrug\u2010Resistant Bacterial Infections in Aged Mice Via Microbiota\u2010Derived Butyrate"],"prefix":"10.1111","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6014-8320","authenticated-orcid":false,"given":"Wenjiao","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine Chinese Academy of Medical Science Beijing China"},{"name":"College of Life Sciences University of Chinese Academy of Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Bo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine Chinese Academy of Medical Science Beijing China"},{"name":"Graduate School of Peking Union Medical College Chinese Academy of Medical Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyan","family":"Jia","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine China Agricultural University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kui","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine China Agricultural University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingfeng","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine Chinese Academy of Medical Science Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,8]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"United Nations Department of Economic and Social Affairs Population Division \u201cWorld Population Prospects 2024\u201d accessed August 14 2025 https:\/\/population.un.org\/wpp\/."},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-023-01233-7"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-020-01746-2"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/fpd.2014.1915"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines11081324"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2015.11.003"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.672353"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix414"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2020.02.022"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2021-003779"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(02)00437-1"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glv229"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1006710"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature18849"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmicrobiol.2016.215"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-019-0568-5"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2021.07.015"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.11.001"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2018.03.006"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2023.111841"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2020.1867054"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14193934"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12574"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i34.3888"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.95316"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.900132"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.4c00915"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules30091888"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-022-01452-3"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102829"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13101170"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12963"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.34133\/research.0378"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0504-5"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20181639"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.34133\/research.0374"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202100749"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-020-0723-z"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2004.04.012"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-024-00722-y"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2018.01.004"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aam9949"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/ps\/82.4.632"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-019-01337-w"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/2.5.801"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-025-01539-3"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.14190"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0169-328x(98)00273-3"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12509"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1021\/cn4000617"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-022-04412-0"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.13722"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2017.1379469"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101422"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.09.060"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.4c05577"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.118928"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S456173"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-5247(24)00079-X"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.113276"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.2217\/fmb-2023-0148"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.1989.sp003298"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2021.08.007"}],"container-title":["Journal of Pineal Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpi.70087","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T11:19:22Z","timestamp":1764155962000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jpi.70087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,8]]},"references-count":63,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/jpi.70087"],"URL":"https:\/\/doi.org\/10.1111\/jpi.70087","archive":["Portico"],"relation":{},"ISSN":["0742-3098","1600-079X"],"issn-type":[{"value":"0742-3098","type":"print"},{"value":"1600-079X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,8]]},"assertion":[{"value":"2025-06-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70087"}}