{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T22:12:43Z","timestamp":1790892763017,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pineal Research"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Melatonin has been shown to travel freely through biological membranes. The consequences of this demonstration have been largely underestimated these past years. In particular, the behavior of melatonin during the preparation of samples from organs (ex vivo), from cells (in cellulo), or subcellular compartment(s) has been experimentally ignored. Melatonin is not retained in samples but can diffuse immediately outside those samples. Similarly, melatonin cannot be \u201ctrapped\u201d in membrane\u2010based organelles like mitochondria, nucleus, ER\/Golgi, or lipid droplets of any sort. Consequently, existing data should be carefully reinterpreted, and future experiments should take the fact of melatonin diffusion into account, in particular when trying to provide convincing experimental evidence for local production of melatonin in cells and organelles outside of the pineal gland and the retina.<\/jats:p>","DOI":"10.1111\/jpi.70142","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T07:19:47Z","timestamp":1775805587000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Melatonin Facts: Musing With the Concept \u201cMelatonin Travels Freely Through Biological Membranes\u201d"],"prefix":"10.1111","volume":"78","author":[{"given":"Jean A.","family":"Boutin","sequence":"first","affiliation":[{"name":"Laboratory of Neuroendocrine Endocrine and Germinal Differentiation and Communication (NorDiC), INSERM, UMR 1239 Univ Rouen Normandie Rouen 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