{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:25:04Z","timestamp":1786116304604,"version":"build-2736575974"},"reference-count":57,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002674","name":"Russian Academy of Sciences","doi-asserted-by":"publisher","award":["FUUU\u20102022\u20100068\u2010122040100036\u20103"],"award-info":[{"award-number":["FUUU\u20102022\u20100068\u2010122040100036\u20103"]}],"id":[{"id":"10.13039\/501100002674","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["RSF 23\u201025\u201000455"],"award-info":[{"award-number":["RSF 23\u201025\u201000455"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pineal Research"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Diabetes mellitus (DM) promotes cardiac arrhythmias, whereas melatonin confers antiarrhythmic effects. Cellular targets modified by DM and melatonin largely overlap, which warrants testing melatonin as an antiarrhythmic agent in DM. Herein, we evaluated electrophysiological and antiarrhythmic properties of melatonin in the experimental DM model. Experiments were performed in 41 control and 71 diabetic rats. 34 diabetic animals were treated with melatonin (orally, 10\u2009mg\/kg daily) for 1 month, and 37 diabetic animals received a placebo. Electrophysiological studies included electrocardiography, in vivo epicardial mapping with induction of ischemia\u2010reperfusion, and patch\u2010clamp studies in ventricular cardiomyocytes. Collagen deposition was assessed in postmortem histological studies. RT\u2010PCR and Western blotting methods were used to estimate\n                    <jats:italic>Gja1<\/jats:italic>\n                    gene expression and Cx43 protein level, respectively. Melatonin treatment in diabetic animals did not influence the level of glycaemia, but mitigated the progression of myocardial fibrosis. Melatonin treatment prevented the DM\u2010related decrease in conduction velocity, increase in duration and dispersion of repolarization, as well as corresponding changes in their electrocardiographic correlates (QRS, QT, and Tpeak\u2010Tend intervals, respectively). Melatonin also prevented the development of reperfusion ventricular tachycardia\/fibrillation. The patch\u2010clamp studies showed that melatonin treatment significantly reduced calcium current, prevented DM\u2010related action potential duration prolongation, but did not modify DM\u2010related increase in sodium current. RT\u2010PCR studies demonstrated that melatonin treatment prevented the DM\u2010related upregulation of\n                    <jats:italic>Gja1<\/jats:italic>\n                    gene expression and increase in Cx43 level. Melatonin treatment of diabetic rats conferred antiarrhythmic effects associated with electrophysiological changes reflected in ECG parameters, which warrants further testing of melatonin in a clinical context.\n                  <\/jats:p>","DOI":"10.1111\/jpi.70153","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T07:37:21Z","timestamp":1780558641000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preventive Antiarrhythmic Properties of Melatonin in Experimental Diabetic Cardiomyopathy in Rats"],"prefix":"10.1111","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1821-9492","authenticated-orcid":false,"given":"Alexey O.","family":"Ovechkin","sequence":"first","affiliation":[{"name":"Department of Cardiac Physiology, Institute of Physiology, Komi Science Center Ural Branch of Russian Academy of Sciences Syktyvkar Komi Republic Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0860-1252","authenticated-orcid":false,"given":"Mikhail A.","family":"Gonotkov","sequence":"additional","affiliation":[{"name":"Department of Cardiac Physiology, Institute of Physiology, Komi Science Center Ural Branch of Russian Academy of Sciences Syktyvkar Komi Republic Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4268-153X","authenticated-orcid":false,"given":"Alena S.","family":"Abramochkina","sequence":"additional","affiliation":[{"name":"Department of Cardiac Physiology, Institute of Physiology, Komi Science Center Ural Branch of Russian Academy of Sciences Syktyvkar Komi Republic Russia"},{"name":"Department of Physiology Pirogov Russian National Research Medical University Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9156-6645","authenticated-orcid":false,"given":"Ekaterina N.","family":"Sedyakina","sequence":"additional","affiliation":[{"name":"Department of Cardiac Physiology, Institute of Physiology, Komi Science Center Ural Branch of Russian Academy of Sciences Syktyvkar Komi Republic Russia"},{"name":"Institute of Medicine Pitirim Sorokin Syktyvkar State University Syktyvkar Komi Republic Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0732-5193","authenticated-orcid":false,"given":"Aleksandra V.","family":"Durkina","sequence":"additional","affiliation":[{"name":"Department of Cardiac Physiology, Institute of Physiology, Komi Science Center Ural Branch of Russian Academy of Sciences Syktyvkar Komi Republic Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9780-1503","authenticated-orcid":false,"given":"Olesya G.","family":"Bernikova","sequence":"additional","affiliation":[{"name":"Department of Cardiac Physiology, Institute of Physiology, Komi Science Center Ural Branch of Russian Academy of Sciences Syktyvkar Komi Republic Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4715-4053","authenticated-orcid":false,"given":"Ilya O.","family":"Velegzhaninov","sequence":"additional","affiliation":[{"name":"Department of Radioecology, Institute of Biology, Komi Science Center, Ural Branch Russian Academy of Sciences Syktyvkar Komi Republic Russia"},{"name":"Center for Molecular and Biological Technologies ITMO University Sankt\u2010Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1779-273X","authenticated-orcid":false,"given":"Jan E.","family":"Azarov","sequence":"additional","affiliation":[{"name":"Department of Cardiac Physiology, Institute of Physiology, Komi Science Center Ural Branch of Russian Academy of Sciences Syktyvkar Komi Republic 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