{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T07:01:16Z","timestamp":1790319676208,"version":"4.1.0"},"reference-count":74,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007801","name":"Fundaci\u00f3n S\u00e9neca","doi-asserted-by":"publisher","award":["21610\/FPI\/21"],"award-info":[{"award-number":["21610\/FPI\/21"]}],"id":[{"id":"10.13039\/100007801","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pineal Research"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The present study investigates the impact of two missense SNPs in the human melanopsin gene\n                    <jats:italic>OPN4<\/jats:italic>\n                    \u2010I394T (rs1079610) and P10L (rs2675703)\u2010 on non\u2010image\u2010forming (NIF) physiological and behavioural outputs in healthy young adults under real\u2010world conditions. Twenty\u2010five healthy university students were genotyped and analysed under a C\u2010allele dominant model for I394T and a T\u2010allele dominant model for P10L. Over 8 days, participants underwent ambulatory monitoring of wrist skin temperature (WT), sleep, activity and light exposure, together with salivary melatonin assessment under five home\u2010based lighting\/time conditions and pupillary light reflex testing. I394T\u2010C carriers exhibited a phase delay in habitual sleep and WT rhythms, reduced WT amplitude, greater internal desynchronization, and lower nocturnal melatonin concentrations under dim light compared to the TT group. Although behavioural and peripheral rhythms were delayed, circadian phase (DLMO) remained preserved, resulting in an increased phase angle of entrainment. On free days, they also showed greater melatonin suppression despite similar light exposure. In contrast, the P10L\u2010T allele was not associated with significant differences in ambulatory, hormonal, or pupillary outcomes. Overall, the I394T variant, but not P10L, significantly associates with NIF physiology in young adults, likely by affecting the coupling between environmental light and downstream circadian outputs, independently of circadian phase. These findings also suggest that I394T\u2010C carriers exhibit features of the circadian phenotype commonly observed in older cohorts, including reduced rhythm robustness and lower melatonin levels, and support a role for this variant in interindividual differences in light sensitivity and circadian function.\n                  <\/jats:p>","DOI":"10.1111\/jpi.70181","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T10:02:05Z","timestamp":1786442525000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Human Melanopsin Gene (\n                    <i>OPN4<\/i>\n                    ) Polymorphisms (I394T, P10L) on Nocturnal Melatonin and Daily Rhythms in Young Adults"],"prefix":"10.1111","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5375-6774","authenticated-orcid":false,"given":"Jes\u00fas","family":"Vicente\u2010Mart\u00ednez","sequence":"first","affiliation":[{"name":"Chronobiology and Sleep Laboratory University of Murcia, Mare Nostrum Campus, IUIE Murcia Spain"},{"name":"Biomedical Research Institute of Murcia Pascual Parrilla\u2013IMIB Murcia Spain"},{"name":"Ciber Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9050-6448","authenticated-orcid":false,"given":"Mar\u00eda \u00c1ngeles","family":"Bonmat\u00ed\u2010Carri\u00f3n","sequence":"additional","affiliation":[{"name":"Biomedical Research Institute of Murcia Pascual Parrilla\u2013IMIB Murcia Spain"},{"name":"Department of Human Anatomy and Psychobiology, Faculty of Medicine University of Murcia, Mare Nostrum Campus Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Mar\u00eda","family":"L\u00f3pez\u2010Parra","sequence":"additional","affiliation":[{"name":"Laboratory of Forensic and Population Genetics, Legal Medicine, Psychiatry and Pathology Department, Faculty of Medicine Complutense University of Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Antonio","family":"Madrid","sequence":"additional","affiliation":[{"name":"Chronobiology and Sleep Laboratory University of Murcia, Mare Nostrum Campus, IUIE Murcia Spain"},{"name":"Biomedical Research Institute of Murcia Pascual Parrilla\u2013IMIB Murcia Spain"},{"name":"Ciber Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1965-3813","authenticated-orcid":false,"given":"Pedro Francisco","family":"Almaida\u2010Pag\u00e1n","sequence":"additional","affiliation":[{"name":"Chronobiology and Sleep Laboratory University of Murcia, Mare Nostrum Campus, IUIE Murcia Spain"},{"name":"Biomedical Research Institute of Murcia Pascual Parrilla\u2013IMIB Murcia Spain"},{"name":"Ciber Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9343-3918","authenticated-orcid":false,"given":"Mar\u00eda Angeles","family":"Rol","sequence":"additional","affiliation":[{"name":"Chronobiology and Sleep Laboratory University of Murcia, Mare Nostrum Campus, IUIE Murcia Spain"},{"name":"Biomedical Research Institute of Murcia Pascual Parrilla\u2013IMIB Murcia Spain"},{"name":"Ciber Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","unstructured":"C. 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