{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T07:01:16Z","timestamp":1790319676038,"version":"4.1.0"},"reference-count":92,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32271916"],"award-info":[{"award-number":["32271916"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pineal Research"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Cadmium (Cd) contamination, a major constraint on plant growth, causes a serious threat to ecological safety.\n                    <jats:italic>Populus tomentosa<\/jats:italic>\n                    is a promising woody species for Cd phytoremediation, but the mechanism of Cd phytoremediation by melatonin (MT) in this species remains unclear. To elucidate how MT confers Cd tolerance in\n                    <jats:italic>P. tomentosa<\/jats:italic>\n                    , four treatments (control, MT: 100\u2009\u03bcmol\u00b7L\n                    <jats:sup>\u22121<\/jats:sup>\n                    melatonin, Cd: 100\u2009\u03bcmol\u00b7L\n                    <jats:sup>\u22121<\/jats:sup>\n                    CdCl\n                    <jats:sub>2<\/jats:sub>\n                    , and MT\u2009+\u2009Cd, CM: 100\u2009\u03bcmol\u00b7L\n                    <jats:sup>\u22121<\/jats:sup>\n                    CdCl\n                    <jats:sub>2<\/jats:sub>\n                    \u2009+\u2009100\u2009\u03bcmol\u00b7L\n                    <jats:sup>\u22121<\/jats:sup>\n                    melatonin) on seedlings were conducted, and integrated analyses of physiological traits, noninvasive micro\u2010test (NMT) data, transcriptomes, and metabolomes were further performed. Cd stress significantly inhibited seedling growth, reduced chlorophyll content, promoted excessive Cd accumulation, and triggered a burst of reactive oxygen species (ROS). Exogenous MT application reversed Cd\u2010induced growth suppression by promoting root Cd\n                    <jats:sup>2+<\/jats:sup>\n                    efflux while reducing Cd influx, decreasing Cd deposition in leaves, and activating superoxide dismutase and peroxidase to scavenge ROS under Cd treatment. Transcriptomic and metabolomic profiling suggested that metabolic pathways, including hormone signaling, glutathione metabolism, and phenylpropanoid biosynthesis, might be participated in the MT\u2010mediated Cd response. Furthermore, three transcription factors, ERF098, bHLH041, and MYB308, were also identified as candidate regulators of MT\u2010mediated Cd detoxification. Heterologous expression in yeast revealed that\n                    <jats:italic>MYB308<\/jats:italic>\n                    not only enhanced Cd tolerance but also reduced Cd accumulation under Cd stress. These findings elucidate the multilayered regulatory network underlying MT\u2010enhanced Cd tolerance in\n                    <jats:italic>P. tomentosa<\/jats:italic>\n                    , and provide genetic resources for breeding Cd\u2010resistant tree varieties and theoretical guidance for remediating Cd\u2010contaminated soils.\n                  <\/jats:p>","DOI":"10.1111\/jpi.70184","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T09:11:36Z","timestamp":1789722696000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multi\u2010Omics Analysis Provides Insights Into the Molecular Mechanism of Melatonin\u2010Mediated Cadmium Tolerance in\n                    <i>Populus tomentosa<\/i>"],"prefix":"10.1111","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1011-7853","authenticated-orcid":false,"given":"Li","family":"Sun","sequence":"first","affiliation":[{"name":"Jiangsu Provincial Key Laboratory for Plant Taxonomy, Resource Conservation and Utilization, Institute of Botany Jiangsu Province and Chinese Academy of Sciences (Nanjing Botanical Garden Mem. Sun Yat\u2010Sen) Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"An","sequence":"additional","affiliation":[{"name":"Jiangsu Provincial Key Laboratory for Plant Taxonomy, Resource Conservation and Utilization, Institute of Botany Jiangsu Province and Chinese Academy of Sciences (Nanjing Botanical Garden Mem. Sun Yat\u2010Sen) Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tengyue","family":"Yan","sequence":"additional","affiliation":[{"name":"Jiangsu Provincial Key Laboratory for Plant Taxonomy, Resource Conservation and Utilization, Institute of Botany Jiangsu Province and Chinese Academy of Sciences (Nanjing Botanical Garden Mem. Sun Yat\u2010Sen) Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2634-1519","authenticated-orcid":false,"given":"Tao","family":"Wang","sequence":"additional","affiliation":[{"name":"Jiangsu Provincial Key Laboratory for Plant Taxonomy, Resource Conservation and Utilization, Institute of Botany Jiangsu Province and Chinese Academy of Sciences (Nanjing Botanical Garden Mem. Sun Yat\u2010Sen) Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochun","family":"Shu","sequence":"additional","affiliation":[{"name":"Jiangsu Provincial Key Laboratory for Plant Taxonomy, Resource Conservation and Utilization, Institute of Botany Jiangsu Province and Chinese Academy of Sciences (Nanjing Botanical Garden Mem. Sun Yat\u2010Sen) Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0498-0435","authenticated-orcid":false,"given":"Zhong","family":"Wang","sequence":"additional","affiliation":[{"name":"Jiangsu Provincial Key Laboratory for Plant Taxonomy, Resource Conservation and Utilization, Institute of Botany Jiangsu Province and Chinese Academy of Sciences (Nanjing Botanical Garden Mem. Sun Yat\u2010Sen) Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[{"name":"College of Modern Agriculture and Life Sciences Weifang University Weifang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8736-3678","authenticated-orcid":false,"given":"Weibing","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Jiangsu Provincial Key Laboratory for Plant Taxonomy, Resource Conservation and Utilization, Institute of Botany Jiangsu Province and Chinese Academy of Sciences (Nanjing Botanical Garden Mem. Sun Yat\u2010Sen) Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42729-021-00645-3"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stress.2026.101271"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scienta.2023.112508"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2024.116768"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12870-026-08539-1"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2020.111851"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2023.141093"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-021-12579-5"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/pcp\/pcaa150"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2023.1144265"},{"issue":"1","key":"e_1_2_10_12_1","first-page":"223","article-title":"An Isopentenyl Transferase Transgenic Wheat Isoline Exhibits Less Seminal Root Growth Impairment and a Differential Metabolite Profile Under Cd Stress","volume":"173","author":"Mansur N. M. G.","year":"2021","journal-title":"Physiologia Plantarum"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3040.2012.02532.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plaphy.2022.07.011"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2020.111887"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/jxb\/ers097"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-023-01512-7"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-015-4882-z"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/jxb\/erae524"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11020309"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plaphy.2020.01.039"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2023.117344"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envexpbot.2020.104291"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scienta.2022.111569"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2024.120002"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2022.130529"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stress.2024.100444"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2021.117218"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plantsci.2017.05.001"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2023.114619"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12937"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2022.995205"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23179855"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2020.618680"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2025.140557"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plaphy.2023.108163"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.124072"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2022.113630"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2022.01.202"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2022.12.176"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.17410"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plaphy.2023.108043"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00299-023-03065-y"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants10010054"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/treephys\/tpad103"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23147593"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2023.1111789"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/f13060947"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2023.131670"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2025.140815"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.52601\/bpr.2024.240009"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1104\/pp.113.215681"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plaphy.2006.12.004"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2023.161751"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plaphy.2019.10.032"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plaphy.2024.109017"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2025.122268"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/treephys\/tpw046"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2024.120138"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00299-023-03027-4"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2023.115217"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scienta.2023.112550"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2023.131039"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/agj2.70116"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00425-023-04146-8"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/pce.70352"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants8080260"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23169456"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2025.120870"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2026.122755"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11040758"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23040799"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2022.870970"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.655885"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hpj.2020.06.002"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2021.130130"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2021.127168"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1080\/07352689.2021.1898083"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2020.112422"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-873009"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.9b07008"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2020.111878"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclepro.2025.144888"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-81046-1"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2017.09.043"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants12040823"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envexpbot.2022.105167"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1111\/pce.70417"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plaphy.2024.109408"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1111\/nph.16008"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tplants.2010.06.005"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00128-015-1502-z"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1093\/jxb\/eraa434"}],"container-title":["Journal of Pineal Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpi.70184","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jpi.70184","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpi.70184","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T06:48:01Z","timestamp":1790318881000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jpi.70184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":92,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/jpi.70184"],"URL":"https:\/\/doi.org\/10.1111\/jpi.70184","archive":["Portico"],"relation":{},"ISSN":["0742-3098","1600-079X"],"issn-type":[{"value":"0742-3098","type":"print"},{"value":"1600-079X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-07-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70184"}}