{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:04:47Z","timestamp":1790762687422,"version":"4.1.0"},"reference-count":70,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pineal Research"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Melatonin (MT) is a secondary metabolite that plays a role in environmental stress response in plants. However, the physiological and molecular mechanisms by which MT alleviates excessive copper (Cu) toxicity in rice (\n                    <jats:italic>Oryza sativa<\/jats:italic>\n                    ) remain unknown. Herein, exogenous MT application increased root and shoot biomass and inhibited the expression of Cu uptake\u2010associated genes, thereby reducing the Cu uptake capacity of the root and Cu concentration\n                    <jats:italic>in vivo<\/jats:italic>\n                    and effectively enhancing Cu stress tolerance compared with Cu treatment. Transcriptome analysis revealed the essential transcription factor\n                    <jats:italic>CARBON STARVED ANTHER<\/jats:italic>\n                    (\n                    <jats:italic>OsCSA<\/jats:italic>\n                    ) as responsive to Cu stress. Compared with the wild type,\n                    <jats:italic>OsCSA<\/jats:italic>\n                    overexpression lines exhibited significantly enhanced Cu tolerance, which was manifested by increased MT content, up\u2010regulated expression of the reactive oxygen species (ROS) scavenging genes\n                    <jats:italic>CATALASE C<\/jats:italic>\n                    and\n                    <jats:italic>ASCORBATE PEROXIDASE<\/jats:italic>\n                    , elevated activities of catalase, superoxide dismutase, and ascorbate peroxidase, and decreased hydrogen peroxide and malondialdehyde content.\n                    <jats:italic>OsCSA<\/jats:italic>\n                    \u2010knockout plants showed the opposite results, and exogenous MT rescued its excessive Cu\u2010sensitive phenotype. Further experiments established that OsCSA directly binds to the GTTA\/TAAC element of\n                    <jats:italic>CAFFEIC ACID O\u2010METHYLTRANSFERASE 12<\/jats:italic>\n                    (\n                    <jats:italic>OsCOMT12<\/jats:italic>\n                    ) promoter, up\u2010regulating its expression. Under Cu stress, significant increases in Cu concentration and ROS accumulation were also observed in loss\u2010of\u2010function\n                    <jats:italic>oscomt12<\/jats:italic>\n                    mutants, consistent with the results observed in\n                    <jats:italic>OsCSA<\/jats:italic>\n                    \u2010knockout lines. Additionally, knockout of\n                    <jats:italic>OsCOMT12<\/jats:italic>\n                    in the\n                    <jats:italic>OsCSA<\/jats:italic>\n                    \u2010overexpression background abolished the positive effect of\n                    <jats:italic>OsCSA<\/jats:italic>\n                    on Cu stress tolerance. These findings establish the OsCSA\u2013OsCOMT12 regulatory module as a new mechanism for MT\u2010mediated Cu stress response in rice, providing a target for genetic improvement of Cu\u2010tolerant crops.\n                  <\/jats:p>","DOI":"10.1111\/jpi.70187","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:37:16Z","timestamp":1790761036000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["OsCSA Acts as an Upstream Activator of OsCOMT12 to Positively Regulate Copper Stress Tolerance in Rice"],"prefix":"10.1111","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3508-7671","authenticated-orcid":false,"given":"Wenli","family":"Lian","sequence":"first","affiliation":[{"name":"Institute of Quality Standard and Monitoring Technology for Agro\u2010products of Guangdong Academy of Agricultural Sciences Guangzhou China"},{"name":"Key Laboratory of Testing and Evaluation for Agro\u2010product Safety and Quality Ministry of Agriculture and Rural Affairs Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Quality &amp; Safety Risk Assessment for Agro\u2010products Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Han","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cotton Bio\u2010breeding and Integrated Utilization, School of Agriculture and Biomanufacturing Zhengzhou University Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3895-3293","authenticated-orcid":false,"given":"Anjing","family":"Geng","sequence":"additional","affiliation":[{"name":"Institute of Quality Standard and Monitoring Technology for Agro\u2010products of Guangdong Academy of Agricultural Sciences Guangzhou China"},{"name":"Key Laboratory of Testing and Evaluation for Agro\u2010product Safety and Quality Ministry of Agriculture and Rural Affairs Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Quality &amp; Safety Risk Assessment for Agro\u2010products Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0034-1191","authenticated-orcid":false,"given":"Qixin","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Quality Standard and Monitoring Technology for Agro\u2010products of Guangdong Academy of Agricultural Sciences Guangzhou China"},{"name":"Key Laboratory of Testing and Evaluation for Agro\u2010product Safety and Quality Ministry of Agriculture and Rural Affairs Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Quality &amp; Safety Risk Assessment for Agro\u2010products Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8742-2170","authenticated-orcid":false,"given":"Shaolong","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Quality Standard and Monitoring Technology for Agro\u2010products of Guangdong Academy of Agricultural Sciences Guangzhou China"},{"name":"Key Laboratory of Testing and Evaluation for Agro\u2010product Safety and Quality Ministry of Agriculture and Rural Affairs Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Quality &amp; Safety Risk Assessment for Agro\u2010products Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6200-2406","authenticated-orcid":false,"given":"Chunfeng","family":"Cai","sequence":"additional","affiliation":[{"name":"Institute of Quality Standard and Monitoring Technology for Agro\u2010products of Guangdong Academy of Agricultural Sciences Guangzhou China"},{"name":"Key Laboratory of Testing and Evaluation for Agro\u2010product Safety and Quality Ministry of Agriculture and Rural Affairs Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Quality &amp; Safety Risk Assessment for Agro\u2010products Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3242-3196","authenticated-orcid":false,"given":"Xiaojie","family":"Zhao","sequence":"additional","affiliation":[{"name":"Institute of Quality Standard and Monitoring Technology for Agro\u2010products of Guangdong Academy of Agricultural Sciences Guangzhou China"},{"name":"Key Laboratory of Testing and Evaluation for Agro\u2010product Safety and Quality Ministry of Agriculture and Rural Affairs Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Quality &amp; Safety Risk Assessment for Agro\u2010products Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4617-0860","authenticated-orcid":false,"given":"Xu","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Quality Standard and Monitoring Technology for Agro\u2010products of Guangdong Academy of Agricultural Sciences Guangzhou China"},{"name":"Key Laboratory of Testing and Evaluation for Agro\u2010product Safety and Quality Ministry of Agriculture and Rural Affairs Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Quality &amp; Safety Risk Assessment for Agro\u2010products Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0347-6720","authenticated-orcid":false,"given":"Guang","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Quality Standard and Monitoring Technology for Agro\u2010products of Guangdong Academy of Agricultural Sciences Guangzhou China"},{"name":"Key Laboratory of Testing and Evaluation for Agro\u2010product Safety and Quality Ministry of Agriculture and Rural Affairs Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Quality &amp; Safety Risk Assessment for Agro\u2010products Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1071\/FP08288","article-title":"Copper in Plants: Acquisition, Transport and Interactions","volume":"36","author":"Yruela I.","year":"2009","journal-title":"Functional Plant Biology"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1515\/eces-2017-0041","article-title":"The Impact of Copper Ions on Oxidative Stress in Garden Cress Lepidium Sativum","volume":"24","author":"Rombel\u2010Bryzek A.","year":"2017","journal-title":"Ecological Chemistry and Engineering S"},{"key":"e_1_2_11_4_1","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/s10534-021-00306-z","article-title":"Copper: Uptake, Toxicity and Tolerance in Plants and Management of Cu\u2010Contaminated Soil","volume":"34","author":"Mir A. 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