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We found that melatonin at millimolar concentrations significantly downregulated transglutaminase 2 (TGM2), histone serotonylation (H3K4me3Q5ser), and YTHDF1\/m\n                    <jats:sup>6<\/jats:sup>\n                    A (N6\u2010methyladenosine) in a colorectal cancer model. Cross\u2010interference between TGM2 and YTHDF1 supports a link between these regulatory processes, while molecular docking, pharmacological interventions, and co\u2010immunoprecipitation experiments suggest the existence of a signaling pathway involving melatonin and the HTR2B receptor. A combined analysis of CHIP\u2010seq and meRIP\u2010seq identified salt\u2010induced kinase 1 (SIK1) as a potential downstream target, and SIK1 interference affected the proliferation and migration of colorectal cancer. Collectively, these findings support a working model in which melatonin\u2010induced tumor suppression is associated with coordinated changes in TGM2\/H3K4me3Q5ser and YTHDF1\u2010associated m\n                    <jats:sup>6<\/jats:sup>\n                    A regulation, with SIK1 emerging as a potential convergent downstream effector.\n                  <\/jats:p>","DOI":"10.1111\/jpi.70192","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T05:26:03Z","timestamp":1791869163000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Melatonin Suppresses Colorectal Cancer Alongside Coordinated Changes in H3K4me3Q5ser and m\n                    <sup>6<\/sup>\n                    A Modifications"],"prefix":"10.1111","volume":"78","author":[{"given":"Wanlu","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Life and Health Sciences Northeastern University  Shenyang China"},{"name":"Wenzhou Institute University of Chinese Academy of Sciences  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2825-0389","authenticated-orcid":false,"given":"Lin","family":"Yuan","sequence":"additional","affiliation":[{"name":"Institute of Neurology, Jiangxi Academy of Clinical Medical Sciences, The First Affiliated Hospital, Jiangxi Medical College Nanchang University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawei","family":"Yu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Biotech Breeding, Institute of Animal Science Chinese Academy of Agricultural Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4353-160X","authenticated-orcid":false,"given":"Shihong","family":"Qi","sequence":"additional","affiliation":[{"name":"College of Life and Health Sciences Northeastern University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Life and Health Sciences Northeastern University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0464-1596","authenticated-orcid":false,"given":"Dongxu","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory Animal Center, College of Animal Science Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenna","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Life and Health Sciences Northeastern University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Life and Health Sciences Northeastern University  Shenyang China"},{"name":"Wenzhou Institute University of Chinese Academy of Sciences  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sihui","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Life and Health Sciences Northeastern University  Shenyang China"},{"name":"Wenzhou Institute University of Chinese Academy of Sciences  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8818-1809","authenticated-orcid":false,"given":"Liting","family":"Lu","sequence":"additional","affiliation":[{"name":"College of Life and Health Sciences Northeastern University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Wu","sequence":"additional","affiliation":[{"name":"Wenzhou Institute University of Chinese Academy of Sciences  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9083-250X","authenticated-orcid":false,"given":"Yongye","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Life and Health Sciences Northeastern University  Shenyang China"},{"name":"National Key Laboratory for Swine Genetic Improvement and Germplasm Innovation, Ministry of Science and Technology of China Jiangxi Agricultural University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.smrv.2025.102069","article-title":"The Impact of Pharmacotherapy for Premenstrual Dysphoric Disorder on Sleep","volume":"80","author":"Meth E. 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