{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T23:35:50Z","timestamp":1772840150089,"version":"3.50.1"},"reference-count":64,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,10,31]],"date-time":"2013-10-31T00:00:00Z","timestamp":1383177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000199","name":"USDA","doi-asserted-by":"crossref","award":["2011-67012-30683"],"award-info":[{"award-number":["2011-67012-30683"]}],"id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2014,8]]},"abstract":"Summary<\/jats:title>To determine how nutrient restriction and melatonin supplementation influence ewe and foetal hepatic and small intestinal energy use, 32 primiparous ewes on d 50 of gestation were fed 60% (RES<\/jats:styled-content>) or 100% (ADQ<\/jats:styled-content>) ofNRC<\/jats:styled-content>recommendations with 0 (CON<\/jats:styled-content>) or 5\u00a0mg\/d (MEL<\/jats:styled-content>) of dietary melatonin. On d 130 of gestation, small intestine and liver were weighed and collected. Data were analysed as a completely randomized design with a 2\u00a0\u00d7\u00a02 factorial arrangement of treatments. Liver weight (g\/kgEBW<\/jats:styled-content>) decreased (p\u00a0=\u00a0<\/jats:italic>0.02) inRES<\/jats:styled-content>ewes. Jejunum weight (g\/kgBW<\/jats:styled-content>) increased (interaction p\u00a0=<\/jats:italic>\u00a00.04) inADQ<\/jats:styled-content>\u2010MEL<\/jats:styled-content>ewes compared with all other treatments. Totalin vitro<\/jats:italic>O2<\/jats:sub>consumption (mol\/min\/tissue) and total citrate synthase activity (mol\/min\/tissue and mol\/min\/kgEBW<\/jats:styled-content>) in liver decreased (p\u00a0\u2264\u00a0<\/jats:italic>0.03) inRES<\/jats:styled-content>ewes. Oxygen consumption (mol\/min\/kgEBW<\/jats:styled-content>) increased (interaction p\u00a0=\u00a00.02) in jejunum ofADQ<\/jats:styled-content>\u2010CON<\/jats:styled-content>versusRES<\/jats:styled-content>\u2010MEL<\/jats:styled-content>andADQ<\/jats:styled-content>\u2010CON<\/jats:styled-content>. Citrate synthase activity (mol\/min\/kg ofEBW<\/jats:styled-content>) increased (interaction p\u00a0=\u00a00.03) in jejunum ofADQ<\/jats:styled-content>\u2010MEL<\/jats:styled-content>compared withRES<\/jats:styled-content>\u2010MEL<\/jats:styled-content>andADQ<\/jats:styled-content>\u2010CON<\/jats:styled-content>. Foetal liver weight (g\/kgBW<\/jats:styled-content>) decreased (p\u00a0=<\/jats:italic>\u00a00.02) inRES<\/jats:styled-content>versusADQ<\/jats:styled-content>. Foetal small intestine weight (g\/kgBW<\/jats:styled-content>) decreased (interaction p\u00a0=<\/jats:italic>\u00a00.05) inRES<\/jats:styled-content>\u2010MEL<\/jats:styled-content>versusADQ<\/jats:styled-content>\u2010MEL<\/jats:styled-content>. Total O2<\/jats:sub>consumption (mol\/min\/tissue) and total citrate synthase activity (mol\/min\/kg ofBW<\/jats:styled-content>) in foetal liver decreased (p\u00a0\u2264\u00a00.05) inRES<\/jats:styled-content>versusADQ<\/jats:styled-content>. Foetal small intestinal O2<\/jats:sub>consumption (mol\/min\/kg ofBW<\/jats:styled-content>) was greater (interaction p\u00a0=<\/jats:italic>\u00a00.03) inRES<\/jats:styled-content>\u2010CON<\/jats:styled-content>andADQ<\/jats:styled-content>\u2010MEL<\/jats:styled-content>thanRES<\/jats:styled-content>\u2010MEL<\/jats:styled-content>andADQ<\/jats:styled-content>\u2010CON<\/jats:styled-content>. Maternal nutrient restriction had a greater effect than melatonin supplementation on liver and jejunum mass and energy utilization in dams and foetuses. Because intestinal mass and energy utilization were more responsive to melatonin supplementation in ewes fed adequate nutrition compared with restricted ewes, melatonin may have limited use as a therapeutic supplement to help overcome potential negative effects of nutrient restriction.<\/jats:p>","DOI":"10.1111\/jpn.12142","type":"journal-article","created":{"date-parts":[[2013,10,31]],"date-time":"2013-10-31T11:06:49Z","timestamp":1383217609000},"page":"797-807","source":"Crossref","is-referenced-by-count":21,"title":["Effects of nutrient restriction and melatonin supplementation on maternal and foetal hepatic and small intestinal energy utilization"],"prefix":"10.1111","volume":"98","author":[{"given":"L. D.","family":"Prezotto","sequence":"first","affiliation":[{"name":"Department of Animal Sciences North Dakota State University Fargo ND USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. O.","family":"Lemley","sequence":"additional","affiliation":[{"name":"Department of Animal and Dairy Sciences Mississippi State University MS USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. E.","family":"Camacho","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences North Dakota State University Fargo ND USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. E.","family":"Doscher","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences North Dakota State University Fargo ND USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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