{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T04:16:17Z","timestamp":1768709777191,"version":"3.49.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,3,10]],"date-time":"2014-03-10T00:00:00Z","timestamp":1394409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Josera Tierern\u00e4hrung, Germany"},{"name":"Alce s.r.l., Bagni di Lucca, Italy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Beginning in the fall of 2010, an increasing and alarming number of cases of calves suffering from liver dystrophy were reported in the south of <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>ermany. An epidemiological investigation was carried out by the authors between <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>ovember 2010 and <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>uly 2011, leading to the implication of a commercial dietary supplement as the potential cause for this outbreak. The components of this product were first tested in a cell culture model and two of them (dietary chestnut extract and glycerol monolaurate) showed a cytotoxic effect. The objective of this study was therefore to evaluate the effect of supplemental feeding of both components alone or in combination on liver function in newborn calves on a commercial dairy farm. Ten calves were enrolled in each of the three treatment groups and the control group (group <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>) following a blocked design. Treatment consisted of supplementation with chestnut extract at 0.02% of birth body mass (<jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content>) (group <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>), supplementation with glycerol monolaurate at 0.006% of <jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content> (group <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>) or a combined treatment (group <jats:styled-content style=\"fixed-case\">CG<\/jats:styled-content>) for five consecutive days. The effect of treatments on liver function was evaluated clinically and by measurement of glutamate dehydrogenase (<jats:styled-content style=\"fixed-case\">GLDH<\/jats:styled-content>) and aspartate aminotransferase (<jats:styled-content style=\"fixed-case\">AST<\/jats:styled-content>) activities as well as the determination of the concentrations of glucose, <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>\u2010lactate and total bilirubin in serum. There was a significant increase in <jats:styled-content style=\"fixed-case\">GLDH<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">AST<\/jats:styled-content> activities and a significant decrease in glucose concentration in treatment groups <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CG<\/jats:styled-content> compared with the control group (p\u00a0\u2264\u00a00.035), whereas no difference was shown for group <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>. Survival was significantly decreased in groups <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> (p\u00a0=\u00a00.029) and <jats:styled-content style=\"fixed-case\">CG<\/jats:styled-content> (p\u00a0=\u00a00.001) compared with both group <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content> and the control group. These results suggest that dietary chestnut extract in an amount of 0.02% of <jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content> alone or in combination has a toxic effect on liver function in newborn calves.<\/jats:p>","DOI":"10.1111\/jpn.12179","type":"journal-article","created":{"date-parts":[[2014,3,10]],"date-time":"2014-03-10T07:54:17Z","timestamp":1394438057000},"page":"190-200","source":"Crossref","is-referenced-by-count":9,"title":["A controlled trial on the effect of feeding dietary chestnut extract and glycerol monolaurate on liver function in newborn calves"],"prefix":"10.1111","volume":"99","author":[{"given":"M.","family":"Wieland","sequence":"first","affiliation":[{"name":"Clinic for Ruminants with Ambulatory and Herd Health Services at the Centre of Clinical Veterinary Medicine LMU Munich Oberschleissheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. K.","family":"Weber","sequence":"additional","affiliation":[{"name":"Bavarian Health and Food Safety Authority Oberschleissheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Hafner\u2010Marx","sequence":"additional","affiliation":[{"name":"Bavarian Health and Food Safety Authority Oberschleissheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Sauter\u2010Louis","sequence":"additional","affiliation":[{"name":"Clinic for Ruminants with Ambulatory and Herd Health Services at the Centre of Clinical Veterinary Medicine LMU Munich Oberschleissheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Bauer","sequence":"additional","affiliation":[{"name":"Institute of Animal Hygiene Technische Universit\u00e4t M\u00fcnchen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Knubben\u2010Schweizer","sequence":"additional","affiliation":[{"name":"Clinic for Ruminants with Ambulatory and Herd Health Services at the Centre of Clinical Veterinary Medicine LMU Munich Oberschleissheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Metzner","sequence":"additional","affiliation":[{"name":"Clinic for Ruminants with Ambulatory and Herd Health Services at the Centre of Clinical Veterinary Medicine LMU Munich Oberschleissheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,3,10]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1","article-title":"Opinion of the scientific panel on additives and products or substances used in animal feed on a request from the commission on the safety and efficacy of the product Farmatan for rabbits and piglets","volume":"222","author":"Anad\u00f3n A.","year":"2005","journal-title":"The EFSA Journal"},{"issue":"2","key":"e_1_2_6_3_1","first-page":"8","article-title":"Interaction of tannin extract and zilpaterol hydrochloride supplementation on feedlot performance of bulls","volume":"91","author":"Barajas R.","year":"2013","journal-title":"Journal of Animal Science"},{"key":"e_1_2_6_4_1","first-page":"407","article-title":"Portacaval shunt in a calf: clinical, pathologic, and ultrasonographic findings","volume":"48","author":"Buczinski S.","year":"2007","journal-title":"The Canadian Veterinary Journal"},{"issue":"2","key":"e_1_2_6_5_1","first-page":"7","article-title":"Influence of tannins extract supplementation on feedlot performance and plasma urea nitrogen of non implanted growing heifers","volume":"91","author":"Cervantes B. J.","year":"2013","journal-title":"Journal of Animal Science"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/00480169.2004.36436"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0442.1998.tb00806.x"},{"key":"e_1_2_6_8_1","first-page":"101","article-title":"Use of a clinical sepsis score for predicting bacteremia in neonatal dairy calves on a calf rearing farm","volume":"38","author":"Fecteau G.","year":"1997","journal-title":"The Canadian Veterinary Journal"},{"key":"e_1_2_6_9_1","first-page":"384","article-title":"In vitro antimicrobial activity of SILVA FEED ENC\u00ae tannin on bacterial strains of poultry origin","volume":"62","author":"Graziani R.","year":"2006","journal-title":"World's Poultry Science Journal"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3923\/ijps.2012.474.481"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.101051"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-006-5048-z"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2011.07.003"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(84)50086-2"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2013-6904"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1532-0456(01)00244-7"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2003.10.021"},{"key":"e_1_2_6_18_1","unstructured":"Lorenz I.;Lorch A. 2010:Klinische Erscheinungen der Azidose beim Durchfallkalb. Neubetrachtung unter dem Gesichtspunkt der D\u2010Laktatazidose. In:K. E.M\u00fcller(ed.)Proceedings of the 8 Berlin\u2010Brandenburgischer Rindertag 2010 October 7\u20139.Cuvillier Verlag G\u00f6ttingen Germany pp.51\u201353"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2009.04.007"},{"key":"e_1_2_6_20_1","volume-title":"Large Animal Neurology","author":"Mayhew I. G.","year":"2009"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.3923\/ijps.2006.873.879"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0377-8401(01)00232-2"},{"key":"e_1_2_6_23_1","first-page":"283","article-title":"High incidence of jaundice in young calves in Southern Germany","volume":"40","author":"Metzner M.","year":"2012","journal-title":"Tier\u00e4rztliche Praxis Ausgabe G, Grosstiere\/Nutztiere"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2005.03.011"},{"key":"e_1_2_6_25_1","unstructured":"Niethammer F. M. 2007:Untersuchungen zur Dehydratation bei K\u00e4lbern mit akuter Diarrhoe unter Ber\u00fccksichtigung ausgew\u00e4hlter klinischer und labordiagnostischer Parameter. Diss Ludwig\u2010Maximilians\u2010University Munich."},{"key":"e_1_2_6_26_1","first-page":"19","volume-title":"Schiff's Diseases of the Liver","author":"Pratt D. S.","year":"2007"},{"key":"e_1_2_6_27_1","first-page":"1851","volume-title":"Veterinary Medicine","author":"Radostits O. M.","year":"2007"},{"key":"e_1_2_6_28_1","first-page":"275","article-title":"Experimental intoxication by Myoporum laetum in cattle","volume":"40","author":"Raposo J. B.","year":"1998","journal-title":"Veterinary and Human Toxicology"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0887-2333(89)90038-6"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0442.2004.00612.x"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00314.2006"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.22358\/jafs\/68004\/2001"},{"key":"e_1_2_6_33_1","first-page":"243","article-title":"Adaptation reaction of dairy calves in the first days of life. Effects of type of delivery and individuality of the newborn","volume":"23","author":"Steinhardt M.","year":"1995","journal-title":"Tier\u00e4rztliche Praxis Ausgabe G, Grosstiere\/Nutztiere"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01151-09"},{"key":"e_1_2_6_35_1","first-page":"136","article-title":"Hypoglycemia in neonatal calves associated with acute diarrhea","volume":"58","author":"Tennant B.","year":"1968","journal-title":"The Cornell Veterinarian"},{"key":"e_1_2_6_36_1","first-page":"29","volume-title":"Labor und Diagnose","author":"Thomas L.","year":"2005"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1053\/rvsc.1999.0345"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.4.1302-1305.2005"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5288(92)90128-O"},{"key":"e_1_2_6_40_1","first-page":"436","article-title":"Rumen involvement in sheep tannic acid metabolism","volume":"37","author":"Zhu J.","year":"1995","journal-title":"Veterinary and Human Toxicology"}],"container-title":["Journal of Animal Physiology and Animal Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjpn.12179","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjpn.12179","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpn.12179","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T16:33:57Z","timestamp":1695573237000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jpn.12179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,10]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["10.1111\/jpn.12179"],"URL":"https:\/\/doi.org\/10.1111\/jpn.12179","archive":["Portico"],"relation":{},"ISSN":["0931-2439","1439-0396"],"issn-type":[{"value":"0931-2439","type":"print"},{"value":"1439-0396","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,10]]}}}