{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:35:04Z","timestamp":1790710504254,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,2,2]],"date-time":"2015-02-02T00:00:00Z","timestamp":1422835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The concept of feeding anionic salts in late gestation is widely used to prevent milk fever in dairy cows. While the effects of these diets on renal Ca excretion and tissue responsiveness towards parathyroid hormone have clearly been demonstrated, data on a potential impact on gastrointestinal Ca absorption are conflicting. Therefore, the aim of this study was to investigate the influence of feeding a diet negative in dietary cation\u2013anion difference (<jats:styled-content style=\"fixed-case\">DCAD<\/jats:styled-content>) on ruminal mineral concentrations, fermentation products, electrophysiological properties of rumen epithelia and Ca flux rates. For this purpose, sheep were kept for 3\u00a0weeks on diets that were either positive or negative in <jats:styled-content style=\"fixed-case\">DCAD<\/jats:styled-content>. The induction of a compensated hyperchloremic metabolic acidosis could be demonstrated by increased plasma Cl and enhanced concentrations of ionised Ca, while plasma concentrations of <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jpn12296-math-0001.png\" xlink:title=\"urn:x-wiley:09312439:media:jpn12296:jpn12296-math-0001\"\/> and base excess were decreased with the low <jats:styled-content style=\"fixed-case\">DCAD<\/jats:styled-content> diet. Neither transmural potential differences nor fermentation products were affected, but ruminal concentrations of Cl and Mg as well as the relation of ionised to total Ca were increased. Ussing chamber experiments revealed alterations of electrophysiological parameters and an increase in the electroneutral component of Ca flux rates from the mucosal to the serosal side of rumen epithelium. As plasma calcitriol concentrations were not affected, it can be concluded that the administration of anionic salts results in a vitamin D\u2010independent stimulation of ruminal Ca transport.<\/jats:p>","DOI":"10.1111\/jpn.12296","type":"journal-article","created":{"date-parts":[[2015,2,3]],"date-time":"2015-02-03T04:49:03Z","timestamp":1422938943000},"page":"156-166","source":"Crossref","is-referenced-by-count":32,"title":["Stimulating effects of a diet negative in dietary cation\u2013anion difference on calcium absorption from the rumen in sheep"],"prefix":"10.1111","volume":"100","author":[{"given":"M.R.","family":"Wilkens","sequence":"first","affiliation":[{"name":"Department of Physiology University of Veterinary Medicine, Foundation Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Praechter","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Veterinary Medicine, Foundation Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Breves","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Veterinary Medicine, Foundation Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Schr\u00f6der","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Veterinary Medicine, Foundation Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5288(94)90147-3"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(84)81657-4"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.1984.sp002844"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0720(15)30158-4"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2007.12.029"},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1186\/BF03546643","article-title":"Prevention of milk fever (hypocalcemic paresis puerperalis) by dietary salt supplements","volume":"16","author":"Dishington I. W.","year":"1975","journal-title":"Acta Veterinaria Scandinavica"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2002.kid568.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0396.1971.tb01573.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0442.1972.tb00300.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/17450390802506885"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/newbio241163a0"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.59.3.318"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(89)79392-9"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022029907002439"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2007.12.020"},{"key":"e_1_2_6_17_1","first-page":"51","article-title":"Role of acid\u2010base physiology on the pathogenesis of parturient hypocalcaemia (milk fever)\u2013the DCAD theory in principal and practice","volume":"97","author":"Goff J. P.","year":"2003","journal-title":"Acta Veterinaria Scandinavica. Supplementum"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2013-7467"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(94)77140-X"},{"key":"e_1_2_6_20_1","volume-title":"Supplemente zu Vorlesungen und \u00dcbungen in der Tierern\u00e4hrung, 10th edn. M. & H","author":"Kamphues J.","year":"2004"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2012-6187"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1051\/rnd:2002003"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2007-0036"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.4141\/cjas89-046"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(07)71637-5"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2006-838"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0396.2006.00651.x"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2005.032078"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19780058"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.1991.sp003530"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.1991.sp003472"},{"key":"e_1_2_6_32_1","volume-title":"Animal Nutrition","author":"McDonald P.","year":"2011"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(00)75091-0"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1071\/AN14344"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0720(15)31053-7"},{"key":"e_1_2_6_36_1","first-page":"1138","article-title":"Use of anionic salts for prevention of milk fever in dairy cattle","volume":"15","author":"Oetzel G. R.","year":"1993","journal-title":"Compendium on Continuing Education for the Practicing Veterinarian"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1159\/000343401"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5288(94)90146-5"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00580.2010"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0720(15)31052-5"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022029906002123"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-6226(94)90091-4"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1466252307001144"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003600050246"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0442.2001.00369.x"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.47.3.567"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/32.1.76"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1139\/y83-207"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0396.2003.00401.x"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(98)75732-7"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpb.2010.11.008"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2011-4342"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2012.06.011"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-008-9931-1"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M306326200"}],"container-title":["Journal of Animal Physiology and Animal Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjpn.12296","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjpn.12296","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpn.12296","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T10:16:42Z","timestamp":1696241802000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jpn.12296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,2]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1111\/jpn.12296"],"URL":"https:\/\/doi.org\/10.1111\/jpn.12296","archive":["Portico"],"relation":{},"ISSN":["0931-2439","1439-0396"],"issn-type":[{"value":"0931-2439","type":"print"},{"value":"1439-0396","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,2]]}}}