{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T20:44:28Z","timestamp":1771188268728,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,4,21]],"date-time":"2015-04-21T00:00:00Z","timestamp":1429574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Biomin GTI GmbH, Herzogenburg, Austria"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>This study was conducted to investigate the impacts of deoxynivalenol (<jats:styled-content style=\"fixed-case\">DON<\/jats:styled-content>) feeding either alone or in combination with a microbial feed additive (<jats:styled-content style=\"fixed-case\">MFA<\/jats:styled-content>) on the immune response to a viral vaccine and serum clinical chemical parameters. Forty 1\u2010day\u2010old boiler chicks were weighed and randomly divided into four groups, 10 birds in each group: (i) control group fed with basal diet; (ii) <jats:styled-content style=\"fixed-case\">DON<\/jats:styled-content> group fed with basal diet artificially contaminated with 10\u00a0mg <jats:styled-content style=\"fixed-case\">DON<\/jats:styled-content>\/kg feed; (iii) <jats:styled-content style=\"fixed-case\">DON<\/jats:styled-content> + <jats:styled-content style=\"fixed-case\">MFA<\/jats:styled-content> group fed with basal diet contaminated with 10\u00a0mg <jats:styled-content style=\"fixed-case\">DON<\/jats:styled-content>\/kg feed and supplemented with 2.5\u00a0kg of <jats:styled-content style=\"fixed-case\">MFA<\/jats:styled-content>\/ton feed; and (iv) <jats:styled-content style=\"fixed-case\">MFA<\/jats:styled-content> group fed with basal diet supplemented with 2.5\u00a0kg of <jats:styled-content style=\"fixed-case\">MFA<\/jats:styled-content>\/ton feed. At 35\u00a0days of age, birds were slaughtered and blood was collected for investigating the antibody titre against infectious bronchitis virus (<jats:styled-content style=\"fixed-case\">IBV<\/jats:styled-content>) and clinical chemical parameters. The results showed that <jats:styled-content style=\"fixed-case\">DON<\/jats:styled-content> reduced (p\u00a0=\u00a00.032) the titre against <jats:styled-content style=\"fixed-case\">IBV<\/jats:styled-content>, decreased (p\u00a0=\u00a00.005) the level of alanine transaminase (<jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content>) (4.2\u00a0\u00b1\u00a00.5\u00a0U\/l) compared with control birds (6.4\u00a0\u00b1\u00a00.5 U\/l), increased (p\u00a0=\u00a00.002) the serum cholesterol concentration (144\u00a0\u00b1\u00a06\u00a0mg\/dl) compared with their control counterparts (123\u00a0\u00b1\u00a05\u00a0mg\/dl) and increased (p\u00a0=\u00a00.074) the amount of circulating triglycerides (62.25\u00a0\u00b1\u00a07.50\u00a0mg\/dl) compared with controls (39.55\u00a0\u00b1\u00a04.74). These results indicate that dietary <jats:styled-content style=\"fixed-case\">DON<\/jats:styled-content> altered the humoral immune response to viral vaccine and affected the serum clinical biochemistry. However, <jats:styled-content style=\"fixed-case\">DON<\/jats:styled-content> in combination with <jats:styled-content style=\"fixed-case\">MFA<\/jats:styled-content> did not affect serum <jats:styled-content style=\"fixed-case\">IBV<\/jats:styled-content> titre. Taken together, <jats:styled-content style=\"fixed-case\">DON<\/jats:styled-content> in the feed of broilers produced an impairment of the success of <jats:styled-content style=\"fixed-case\">IBV<\/jats:styled-content> vaccine and affected the health of birds.<\/jats:p>","DOI":"10.1111\/jpn.12328","type":"journal-article","created":{"date-parts":[[2015,4,21]],"date-time":"2015-04-21T06:25:27Z","timestamp":1429597527000},"page":"53-60","source":"Crossref","is-referenced-by-count":23,"title":["Deoxynivalenol in chicken feed alters the vaccinal immune response and clinical biochemical serum parameters but not the intestinal and carcass characteristics"],"prefix":"10.1111","volume":"100","author":[{"given":"K.","family":"Ghareeb","sequence":"first","affiliation":[{"name":"Department for Farm Animals and Veterinary Public Health Institute of Animal Nutrition and Functional Plant Compounds University of Veterinary Medicine Vienna Vienna Austria"},{"name":"Department of Animal Behaviour and Management Faculty of Veterinary Medicine South Valley University Qena Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. A.","family":"Awad","sequence":"additional","affiliation":[{"name":"Clinic for Poultry and Fish Medicine Department for Farm Animals and Veterinary Public Health University of Veterinary Medicine Vienna Vienna Austria"},{"name":"Department of Animal Hygiene, Poultry and Environment Faculty of Veterinary Medicine South Valley University Qena Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q.","family":"Zebeli","sequence":"additional","affiliation":[{"name":"Department for Farm Animals and Veterinary Public Health Institute of Animal Nutrition and Functional Plant Compounds University of Veterinary Medicine Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"B\u00f6hm","sequence":"additional","affiliation":[{"name":"Department for Farm Animals and Veterinary Public Health Institute of Animal Nutrition and Functional Plant Compounds University of Veterinary Medicine Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps.2011-01813"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps.2007-00341"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1007\/s00204-014-1284-9","article-title":"The feed contaminant deoxynivalenol affects the intestinal barrier permeability through inhibition of protein synthesis","volume":"89","author":"Awad W. 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