{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T16:06:07Z","timestamp":1785427567601,"version":"3.56.0"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,11,28]],"date-time":"2015-11-28T00:00:00Z","timestamp":1448668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005881","name":"Emberi Eroforr\u00e1sok Miniszt\u00e9riuma","doi-asserted-by":"publisher","award":["9877\u20103\/2015\/FEKUT"],"award-info":[{"award-number":["9877\u20103\/2015\/FEKUT"]}],"id":[{"id":"10.13039\/501100005881","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003549","name":"Orsz\u00e1gos Tudom\u00e1nyos Kutat\u00e1si Alapprogramok","doi-asserted-by":"publisher","award":["114033"],"award-info":[{"award-number":["114033"]}],"id":[{"id":"10.13039\/501100003549","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2016,8]]},"abstract":"Summary<\/jats:title>The expression of hepatic drug\u2010metabolizing cytochrome P450 (CYP<\/jats:styled-content>) enzymes may be affected by several nutrition\u2010derived compounds, such as by the commonly applied feed additive butyrate, possibly leading to feed\u2013drug interactions. The aim of this study was to provide some evidence if butyrate can alter the activity of hepatic CYP<\/jats:styled-content>s in chickens exposed to CYP<\/jats:styled-content>\u2010inducing xenobiotics, monitoring for the first time the possibility of such interaction. Ross 308 chickens in the grower phase were treated with daily intracoelomal phenobarbital (PB<\/jats:styled-content>) injection (80\u00a0mg\/kg BW<\/jats:styled-content>), applied as a non\u2010specific CYP<\/jats:styled-content>\u2010inducer, simultaneously with two different doses of intra\u2010ingluvial sodium butyrate boluses (0.25 and 1.25\u00a0g\/kg BW<\/jats:styled-content>) for 5 days. Activity of CYP<\/jats:styled-content>2H and CYP<\/jats:styled-content>3A subfamilies was assessed by specific enzyme assays from isolated liver microsomes. According to our results, the lower dose of orally administered butyrate significantly attenuated the PB<\/jats:styled-content>\u2010triggered elevation of both hepatic CYP<\/jats:styled-content>2H and CYP<\/jats:styled-content>3A activities, which might be in association with the partly common signalling pathways of butyrate and CYP<\/jats:styled-content>\u2010inducing drugs, such as that of PB<\/jats:styled-content>. Based on these data, butyrate may take part in pharmacoepigenetic interactions with simultaneously applied drugs or other CYP<\/jats:styled-content>\u2010inducing xenobiotics, with possible consequences for food safety and pharmacotherapy. Butyrate was found to be capable to maintain physiological CYP<\/jats:styled-content> activity by attenuating CYP<\/jats:styled-content> induction, underlining the safety of butyrate application in poultry nutrition.<\/jats:p>","DOI":"10.1111\/jpn.12416","type":"journal-article","created":{"date-parts":[[2015,11,28]],"date-time":"2015-11-28T07:54:38Z","timestamp":1448697278000},"page":"637-642","source":"Crossref","is-referenced-by-count":5,"title":["Feed\u2013drug interaction of orally applied butyrate and phenobarbital on hepatic cytochrome P450 activity in chickens"],"prefix":"10.1111","volume":"100","author":[{"given":"G.","family":"M\u00e1tis","sequence":"first","affiliation":[{"name":"Department of Physiology and Biochemistry Faculty of Veterinary Science Szent Istv\u00e1n University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Kulcs\u00e1r","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biochemistry Faculty of Veterinary Science Szent Istv\u00e1n University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Petrilla","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biochemistry Faculty of Veterinary Science Szent Istv\u00e1n University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Herm\u00e1ndy\u2010Berencz","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biochemistry Faculty of Veterinary Science Szent Istv\u00e1n University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zs.","family":"Neogr\u00e1dy","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biochemistry Faculty of Veterinary Science Szent Istv\u00e1n University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,28]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Ross Broiler Management Manual","author":"Anonymous","year":"2009"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00000897"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvp.12109"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-7-181"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/9783527630905.ch8"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.clpt.6100148"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/dna.1.1989.8.179"},{"key":"e_1_2_6_9_1","first-page":"942","article-title":"Effects of bicyclol on aflatoxin B and hepatotoxicity in rats","volume":"23","author":"Hong L. 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