{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T19:14:18Z","timestamp":1721848458477},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,12,14]],"date-time":"2015-12-14T00:00:00Z","timestamp":1450051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>This study was carried out to investigate the effect of dietary supplementation with molecular or nano\u2010clay binders on biochemical and histopathological examination of organs of turkeys fed diets contaminated with aflatoxin B<jats:sub>1.<\/jats:sub> Two hundred and sixteen unsexed 1\u2010day\u2010old British United Turkeys were randomly allotted to nine diets in a 3\u00a0\u00d7\u00a03 factorial arrangement of diets supplemented with no toxin binder, molecular toxin binder (<jats:styled-content style=\"fixed-case\">MTB<\/jats:styled-content>) and nano\u2010clay toxin binder, each contaminated with 0, 60 and 110\u00a0ppb aflatoxin B<jats:sub>1<\/jats:sub> respectively. There were three replicates per treatment with eight turkeys per replicate. Biochemical analyses, organ weights and histopathological changes of some organs were examined at the end of the study which lasted for 84 days. Turkeys fed diets supplemented with molecular and nano\u2010binders showed higher (p\u00a0&lt;\u00a00.001) total serum protein, reduced (p\u00a0&lt;\u00a00.001) serum uric acid and GGT concentration values when compared with those fed aflatoxin\u2010contaminated diets supplemented with no binder. Turkeys fed aflatoxin\u2010contaminated diets supplemented with no binder had increased (p\u00a0&lt;\u00a00.001) AST and ALT concentration when compared with other treatments. The heaviest (p\u00a0&lt;\u00a00.001) liver and intestinal weight was noticed with turkeys fed diets supplemented with no binder and contaminated with 110\u00a0ppb aflatoxin B<jats:sub>1<\/jats:sub>. Pathologically, there was no visible morphological alteration noticed in all turkeys fed uncontaminated diets and nano\u2010clay\u2010supplemented group. Hepatic paleness, hepatomegaly and yellowish discolouration of the liver were observed with turkeys fed diets containing no binder but contaminated with 60 and 110\u00a0ppb aflatoxin B1. Intestinal histopathological changes such as goblet cell hyperplasia, villous atrophy and diffuse lymphocytic enteritis were more prominent in turkeys fed diets containing no toxin binder and <jats:styled-content style=\"fixed-case\">MTB<\/jats:styled-content>. In conclusion, there were improved biochemical parameters and reduced deleterious effects of aflatoxin B<jats:sub>1<\/jats:sub> in turkeys fed diet supplemented with clay binders. However, the improvement was more conspicuous in the nano\u2010clay\u2010supplemented group than molecular clay group.<\/jats:p>","DOI":"10.1111\/jpn.12421","type":"journal-article","created":{"date-parts":[[2015,12,14]],"date-time":"2015-12-14T09:50:14Z","timestamp":1450086614000},"page":"1191-1202","source":"Crossref","is-referenced-by-count":6,"title":["Effect of dietary supplementation with clay\u2010based binders on biochemical and histopathological changes in organs of turkey fed with aflatoxin\u2010contaminated diets"],"prefix":"10.1111","volume":"100","author":[{"given":"A. O.","family":"Lala","sequence":"first","affiliation":[{"name":"Institute of Food Security, Environmental Resources and Agricultural Research Federal University of Agriculture Abeokuta Ogun State Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O. L.","family":"Ajayi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology College of Veterinary Medicine Federal University of Agriculture Abeokuta Ogun State Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. O.","family":"Oso","sequence":"additional","affiliation":[{"name":"Department of Animal Nutrition Federal University of Agriculture Abeokuta Ogun State Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. O.","family":"Ajao","sequence":"additional","affiliation":[{"name":"Department of Animal Nutrition Federal University of Agriculture Abeokuta Ogun State Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O. 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