{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:44:12Z","timestamp":1777553052268,"version":"3.51.4"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,2,5]],"date-time":"2016-02-05T00:00:00Z","timestamp":1454630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The effect of mannitol on bone\u2010related mineral absorption and retention and the mechanism was investigated in this study. Fourteen 8\u2010week\u2010old male Wistar rats in experiment 1 and same number and age cecectomized Wistar male rats in experiment 2 were divided into two subgroups of seven animals, respectively, fed diets containing 0 or 4% mannitol for 28\u00a0days. Mineral balance tests were determined twice during days 8\u201312 and days 22\u201326, and the rats were slaughtered on day 28 both in experiment 1 and experiment 2. The whole caecum and colon were collected with the content to analyse tissue weight, content weight, content's <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> and moisture, organic acids' concentration and mineral levels. In experiment 1, Ca absorption and retention and Mg absorption were significantly increased by mannitol feeding during days 8\u201312. Caecal total weight, tissue weight and content weight were increased, the <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> of caecum and colon was reduced, and the concentrations of caecal short\u2010chain fatty acids (<jats:styled-content style=\"fixed-case\">SCFA<\/jats:styled-content>s) were modified by mannitol feeding. In experiment 2, during days 8\u201312 and days 22\u201326, Ca absorption and retention were significantly lowered by mannitol feeding in cecectomized rats; however, mannitol feeding decreased Mg absorption during days 8\u201312, but did not impact Mg retention. Colonic total weight, tissue weight and content weight were significantly increased, and colonic pH was reduced by mannitol feeding. In conclusion, dietary mannitol increased the absorption of Ca and Mg and the caecum markedly contributed to this promoting effect of mannitol.<\/jats:p>","DOI":"10.1111\/jpn.12435","type":"journal-article","created":{"date-parts":[[2016,2,5]],"date-time":"2016-02-05T11:59:09Z","timestamp":1454673549000},"page":"715-722","source":"Crossref","is-referenced-by-count":5,"title":["Dietary mannitol increased the absorption of calcium and\u00a0magnesium in rats"],"prefix":"10.1111","volume":"100","author":[{"given":"J.","family":"Xiao","sequence":"first","affiliation":[{"name":"Division of Bioscience Graduate School of Natural Science and Technology Okayama University Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Sakaguchi","sequence":"additional","affiliation":[{"name":"Division of Bioscience Graduate School of Natural Science and Technology Okayama University Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Min","sequence":"additional","affiliation":[{"name":"Division of Bioscience Graduate School of Natural Science and Technology Okayama University Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Kawasaki","sequence":"additional","affiliation":[{"name":"Division of Bioscience Graduate School of Natural Science and Technology Okayama University Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,5]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1995.tb04466.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1016256619309"},{"key":"e_1_2_5_4_1","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1093\/jn\/118.6.793","article-title":"Influence of the disaccharide lactitol on intestinal absorption and body retention of calcium in rats","volume":"118","author":"Ammann P.","year":"1988","journal-title":"Journal of Nutrition"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1079\/PNS2002215"},{"key":"e_1_2_5_6_1","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1128\/jb.87.5.1246-1248.1964","article-title":"Metabolism of mannitol and induction of mannitol 1\u2010phosphate dehydrogenase in Lactobacillus plantarum","volume":"87","author":"Chakravorty M.","year":"1964","journal-title":"Journal of Bacteriology"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.41.95"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-005-1470-y"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-006-0092-x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-003-0390-x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-4-29"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndtplus\/sfr164"},{"key":"e_1_2_5_13_1","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1128\/jb.96.2.472-478.1968","article-title":"Fermentation of glucose, lactose, galactose, mannitol, and xylose by bifidobacteria","volume":"96","author":"Vries W.","year":"1968","journal-title":"Journal of Bacteriology"},{"key":"e_1_2_5_14_1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1093\/jn\/115.1.53","article-title":"Stimulation of absorption of volatile fatty acids and minerals in the cecum of rats adapted to a very high fiber diet","volume":"115","author":"Demign\u00e9 C.","year":"1985","journal-title":"Journal of Nutrition"},{"key":"e_1_2_5_15_1","first-page":"22","article-title":"Organic mineral allow for greater absorption","volume":"83","author":"Garret J.","year":"2011","journal-title":"Feedstuffs"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.56.387"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/128.5.843"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1538\/expanim.53.361"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01296104"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02087426"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1079\/NRR200371"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.1991.sp003530"},{"key":"e_1_2_5_23_1","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1128\/jb.124.3.1475-1481.1975","article-title":"Mannitol transport in Streptococcus mutans","volume":"124","author":"Maryanski J. 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