{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:54:31Z","timestamp":1787504071559,"version":"build-2736575974"},"reference-count":54,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,3,2]],"date-time":"2016-03-02T00:00:00Z","timestamp":1456876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2017,8]]},"abstract":"Summary<\/jats:title>\n \n Using a model to generate experimental groups with different manifestations of\n post\u2010partum<\/jats:italic>\n (p.p.) fat mobilization and ketogenesis, the effects of a dietary and a medical intervention on biochemical and haematological parameters, antibody titre, leucocytes subsets and function of transition cows were examined. In total, 60 German Holstein cows were allocated 6\u00a0weeks\n antepartum<\/jats:italic>\n (a.p.) to 3 high\u2010body condition score (\n BCS<\/jats:styled-content>\n ) groups (\n BCS<\/jats:styled-content>\n 3.95) and 1 low\u2010\n BCS<\/jats:styled-content>\n group (\n LC<\/jats:styled-content>\n ,\n BCS<\/jats:styled-content>\n 2.77). High\u2010\n BCS<\/jats:styled-content>\n cows received a monensin controlled\u2010release capsule (\n HC<\/jats:styled-content>\n \/\n MO<\/jats:styled-content>\n ) or a blend of essential oils (\n HC<\/jats:styled-content>\n \/\n EO<\/jats:styled-content>\n ) or formed a control group (\n HC<\/jats:styled-content>\n ). Parameters were evaluated in 3 periods (day (d) \u221242 until calving, 1 until 14\u00a0days in milk (\n DIM<\/jats:styled-content>\n ), 15 until 56\n DIM<\/jats:styled-content>\n ).\n <\/jats:p>\n \n Over the course of trial, various parameters were influenced by period with greatest variability next to calving. White blood cell count was higher in the\n HC<\/jats:styled-content>\n (8.42\u00a0\u00d7\u00a010\n 3<\/jats:sup>\n \/\n \u03bc<\/jats:italic>\n l) and\n HC<\/jats:styled-content>\n \/\n EO<\/jats:styled-content>\n (8.38\u00a0\u00d7\u00a010\n 3<\/jats:sup>\n \/\n \u03bc<\/jats:italic>\n l) groups than in the\n HC<\/jats:styled-content>\n \/\n MO<\/jats:styled-content>\n group (6.81\u00a0\u00d7\u00a010\n 3<\/jats:sup>\n \/\n \u03bc<\/jats:italic>\n l) considering the whole trial. Supplementation of monensin decreased aspartate aminotransferase in comparison with the\n HC<\/jats:styled-content>\n group similar to\n LC<\/jats:styled-content>\n treatment. Bilirubin concentration was nearly doubled in all high\u2010\n BCS<\/jats:styled-content>\n cows in period 2. In period 3, essential oils increased\n \u03b3<\/jats:italic>\n \u2010glutamyltransferase (80.4\u00a0Units\/l) in comparison with all other groups and glutamine dehydrogenase (61\u00a0Units\/l) in comparison with the\n LC<\/jats:styled-content>\n (19\u00a0Units\/l) and the\n HC<\/jats:styled-content>\n \/\n MO<\/jats:styled-content>\n group (18\u00a0Units\/l).\n <\/jats:p>\n \n Results suggest that parameters were generally characterized by a high variability around calving. Based on biochemical characteristics, it appeared that the\n HC<\/jats:styled-content>\n cows seemed to have compromised hepatocyte integrity when compared to the\n LC<\/jats:styled-content>\n cows. From the immune parameters investigated, the\n BVDV<\/jats:styled-content>\n antibody response was more pronounced in\n HC<\/jats:styled-content>\n \/\n MO<\/jats:styled-content>\n compared to\n HC<\/jats:styled-content>\n \/\n EO<\/jats:styled-content>\n .\n <\/jats:p>","DOI":"10.1111\/jpn.12494","type":"journal-article","created":{"date-parts":[[2016,3,2]],"date-time":"2016-03-02T22:57:04Z","timestamp":1456959424000},"page":"791-806","source":"Crossref","is-referenced-by-count":21,"title":["Effects of monensin and essential oils on immunological, haematological and biochemical parameters of cows during the\u00a0transition period"],"prefix":"10.1111","volume":"101","author":[{"given":"C.","family":"Drong","sequence":"first","affiliation":[{"name":"Institute of Animal Nutrition Friedrich\u2010Loeffler\u2010Institut Federal Research Institute for Animal Health Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Meyer","sequence":"additional","affiliation":[{"name":"Institute of Animal Nutrition Friedrich\u2010Loeffler\u2010Institut Federal Research Institute for Animal Health Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"von Soosten","sequence":"additional","affiliation":[{"name":"Institute of Animal Nutrition Friedrich\u2010Loeffler\u2010Institut Federal Research Institute for Animal Health Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Frahm","sequence":"additional","affiliation":[{"name":"Institute of Animal Nutrition Friedrich\u2010Loeffler\u2010Institut Federal Research Institute for Animal Health Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Rehage","sequence":"additional","affiliation":[{"name":"Clinic for Cattle University of Veterinary Medicine, Foundation Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Schirrmeier","sequence":"additional","affiliation":[{"name":"Institute of Diagnostic Virology Friedrich\u2010Loeffler\u2010Institut Federal Research Institute for Animal Health Greifswald\u2010Insel Riems Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Beer","sequence":"additional","affiliation":[{"name":"Institute of Diagnostic Virology Friedrich\u2010Loeffler\u2010Institut Federal Research Institute for Animal Health Greifswald\u2010Insel Riems Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"D\u00e4nicke","sequence":"additional","affiliation":[{"name":"Institute of Animal Nutrition Friedrich\u2010Loeffler\u2010Institut Federal Research Institute for Animal Health Braunschweig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(04)73446-3"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cimid.2011.01.004"},{"key":"e_1_2_6_4_1","first-page":"208","article-title":"The impact of controlled release capsules of monensin on postcalving haptoglobin concentrations in dairy cattle","volume":"69","author":"Crawford R. 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