{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T13:23:06Z","timestamp":1789392186080,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,6,8]],"date-time":"2016-06-08T00:00:00Z","timestamp":1465344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002507","name":"Kangwon National University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002507","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The present study was performed to investigate the effects of dietary supplementation of bacteriophages (phages) against enterotoxigenic <jats:italic>Escherichia coli<\/jats:italic> (ETEC) K88 as a therapy against the ETEC infection in post\u2010weaning pigs. Two groups of post\u2010weaning pigs aged 35\u00a0days, eight animals per group, were challenged with 3.0\u00a0\u00d7\u00a010<jats:sup>10<\/jats:sup> colony forming units of ETEC K88, a third group given the vehicle. The unchallenged group and one challenged group were fed a basal nursery diet for 14\u00a0days while the remaining challenged group was fed the basal diet supplemented with 1.0\u00a0\u00d7\u00a010<jats:sup>7<\/jats:sup> plaque forming units of the phage per kg. Average daily gain (ADG), goblet cell density and villous height:crypt depth (VH:CD) ratio in the intestine were less in the challenged group than in the unchallenged group within the animals fed the basal diet (p\u00a0&lt;\u00a00.05); the reverse was true for rectal temperature, faecal consistency score (FCS), <jats:italic>E.\u00a0coli<\/jats:italic> adhesion score (EAS) in the intestine, serum interleukin\u20108 (IL\u20108) and tumour necrosis factor\u2010\u03b1 (TNF\u2010\u03b1) concentrations and digesta pH in the stomach, caecum and colon. The ETEC infection symptom within the challenged animals was alleviated by the dietary phage supplementation (p\u00a0&lt;\u00a00.05) in ADG, FCS, EAS in the jejunum, serum TNF\u2010\u03b1 concentration, digesta pH in the colon, goblet cell density in the ileum and colon and VH:CD ratio in the ileum. Moreover, the infection symptom tended to be alleviated (p\u00a0&lt;\u00a00.10) by the phage supplementation in rectal temperature, EAS in the ileum and caecum, and VH:CD ratio in the duodenum and jejunum. However, EAS in the colon, digesta pH in the stomach and caecum, and goblet cell density in the jejunum did not change due to the dietary phage. Overall, results indicate that the phage therapy is effective for alleviation of acute ETEC K88 infection in post\u2010weaning pigs.<\/jats:p>","DOI":"10.1111\/jpn.12513","type":"journal-article","created":{"date-parts":[[2016,6,8]],"date-time":"2016-06-08T06:47:01Z","timestamp":1465368421000},"page":"88-95","source":"Crossref","is-referenced-by-count":47,"title":["Effects of dietary supplementation of bacteriophages against enterotoxigenic <i>Escherichia coli<\/i> (ETEC) K88 on clinical symptoms of post\u2010weaning pigs challenged with the ETEC pathogen"],"prefix":"10.1111","volume":"101","author":[{"given":"C. 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