{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T19:03:43Z","timestamp":1790535823253,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,3,16]],"date-time":"2017-03-16T00:00:00Z","timestamp":1489622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000978","name":"Australian Pork Limited","doi-asserted-by":"publisher","award":["2012\/2423"],"award-info":[{"award-number":["2012\/2423"]}],"id":[{"id":"10.13039\/501100000978","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Heat stress (<jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>) disrupts redox balance and insulin\u2010related metabolism. Supplementation with supranutritional amounts of selenium (Se) may enhance glutathione peroxidase (<jats:styled-content style=\"fixed-case\">GPX<\/jats:styled-content>) activity and reduce oxidative stress, but may trigger insulin resistance. Therefore, the aim of this experiment was to investigate the effects of a short\u2010term high Se supplementation on physiology, oxidative stress and insulin\u2010related metabolism in heat\u2010stressed pigs. Twenty\u2010four gilts were fed either a control (0.20\u00a0ppm Se) or a high Se (1.0\u00a0ppm Se yeast, HiSe) diet for 2\u00a0weeks. Pigs were then housed in thermoneutral (20\u00b0C) or <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> (35\u00b0C) conditions for 8\u00a0days. Blood samples were collected to study blood Se and oxidative stress markers. An oral glucose tolerance test (<jats:styled-content style=\"fixed-case\">OGTT<\/jats:styled-content>) was conducted on day 8 of thermal exposure. The <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> conditions increased rectal temperature and respiration rate (both <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). The HiSe diet increased blood Se by 12% (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05) and ameliorated the increase in rectal temperature (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). Heat stress increased oxidative stress as evidenced by a 48% increase in plasma advanced oxidized protein products (<jats:styled-content style=\"fixed-case\">AOPP<\/jats:styled-content>s; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05), which may be associated with the reductions in plasma biological antioxidant potential (<jats:styled-content style=\"fixed-case\">BAP<\/jats:styled-content>) and erythrocyte <jats:styled-content style=\"fixed-case\">GPX<\/jats:styled-content> activity (both <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). The HiSe diet did not alleviate the reduction in plasma <jats:styled-content style=\"fixed-case\">BAP<\/jats:styled-content> or increase in <jats:styled-content style=\"fixed-case\">AOPP<\/jats:styled-content>s observed during <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>, although it tended to increase erythrocyte <jats:styled-content style=\"fixed-case\">GPX<\/jats:styled-content> activity by 13% (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.068). Without affecting insulin, <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> attenuated lipid mobilization, as evidenced by a lower fasting <jats:styled-content style=\"fixed-case\">NEFA<\/jats:styled-content> concentration (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05), which was not mitigated by the HiSe diet. The HiSe diet increased insulin <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>, suggesting it potentiated insulin resistance, although this only occurred under <jats:styled-content style=\"fixed-case\">TN<\/jats:styled-content> conditions (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.066). In summary, <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> induced oxidative stress and attenuated lipid mobilization in pigs. The short\u2010term supranutritional Se supplementation alleviated hyperthermia, but did not protect against oxidative stress in heat\u2010stressed pigs.<\/jats:p>","DOI":"10.1111\/jpn.12689","type":"journal-article","created":{"date-parts":[[2017,3,16]],"date-time":"2017-03-16T05:52:52Z","timestamp":1489643572000},"page":"276-285","source":"Crossref","is-referenced-by-count":32,"title":["Effects of a short\u2010term supranutritional selenium supplementation on redox balance, physiology and insulin\u2010related metabolism in heat\u2010stressed pigs"],"prefix":"10.1111","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2644-2416","authenticated-orcid":false,"given":"F.","family":"Liu","sequence":"first","affiliation":[{"name":"Faculty of Veterinary and Agricultural Sciences The University of Melbourne  Parkville VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Celi","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary and Agricultural Sciences The University of Melbourne  Parkville VIC Australia"},{"name":"DSM Nutritional Products  Columbia MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. J.","family":"Cottrell","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary and Agricultural Sciences The University of Melbourne  Parkville VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. S.","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary and Agricultural Sciences The University of Melbourne  Parkville VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. J.","family":"Leury","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary and Agricultural Sciences The University of Melbourne  Parkville VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. 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