{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:51:33Z","timestamp":1791589893751,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,3,9]],"date-time":"2017-03-09T00:00:00Z","timestamp":1489017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Pet Nutrition Center, Hill\u2019s Pet Nutrition, Inc, Topeka, KS"},{"name":"IDEXX Laboratories, Inc"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2018,2]]},"abstract":"Summary<\/jats:title>Currently, nutritional management is recommended when serum creatinine (Cr) exceeds 1.4\u00a0mg\/dl in dogs with IRIS<\/jats:styled-content>\u2010Stage 2 chronic kidney disease (CKD<\/jats:styled-content>) to slow progressive loss of kidney function, reduce clinical and biochemical consequences of CKD<\/jats:styled-content>, and maintain adequate nutrition. It is unknown if dietary interventions benefit non\u2010azotemic dogs at earlier stages. A prospective 12\u2010month feeding trial was performed in client\u2010owned dogs with IRIS<\/jats:styled-content>\u2010Stage 1 CKD<\/jats:styled-content> (n<\/jats:italic>\u00a0=\u00a036; 20 had persistently dilute urine with urine specific gravity (USG<\/jats:styled-content>) <1.020 without identifiable non\u2010renal cause; six had persistent proteinuria of renal origin with urine protein creatinine (UPC<\/jats:styled-content>) ratio >0.5; 10 had both). Ease of transition to therapeutic renal food and effects on renal biomarkers and quality of life attributes were assessed. Dogs were transitioned over 1\u00a0week from grocery\u2010branded foods to renal food. At 0, 3, 6, 9, and 12\u2010months a questionnaire to assess owner's perception of their pet's acceptance of renal food and quality of life was completed. Renal biomarkers, including serum Cr, blood urea nitrogen (BUN<\/jats:styled-content>), and symmetric dimethylarginine (SDMA<\/jats:styled-content>), and USG<\/jats:styled-content> and UPC<\/jats:styled-content> ratio were measured. Of 36 dogs initially enrolled, 35 (97%) dogs were transitioned to therapeutic renal food. Dogs moderately or extremely liked the food 88% of the time, ate most or all of the food 84% of the time, and were moderately or extremely enthusiastic while eating 76% of the time. All renal biomarkers (Cr, BUN<\/jats:styled-content>, and SDMA<\/jats:styled-content>) were decreased (p\u00a0<\/jats:italic>\u2264\u00a0<\/jats:italic>.05) from baseline at 3\u2010months, and remained decreased from baseline at 12\u2010months in dogs completing the study (n<\/jats:italic>\u00a0=\u00a020). Proteinuria was reduced in 12 of 16 dogs (p\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.045) with proteinuria. Owners reported improvement in overall health and quality of life attributes, and hair and coat quality (all p\u00a0<\/jats:italic><\u00a0<\/jats:italic>.01). In summary, dogs with IRIS<\/jats:styled-content>\u2010Stage 1 CKD<\/jats:styled-content> readily transition to renal food. Decreasing serum biomarker concentrations and reduction in proteinuria suggest stabilized kidney function.<\/jats:p>","DOI":"10.1111\/jpn.12692","type":"journal-article","created":{"date-parts":[[2017,3,9]],"date-time":"2017-03-09T06:33:01Z","timestamp":1489041181000},"page":"297-307","source":"Crossref","is-referenced-by-count":25,"title":["A longitudinal study on the acceptance and effects of a therapeutic renal food in pet dogs with IRIS<\/scp>\u2010Stage 1 chronic kidney disease"],"prefix":"10.1111","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7758-6703","authenticated-orcid":false,"given":"J. A.","family":"Hall","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences College of Veterinary Medicine Oregon State University Corvallis OR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. A.","family":"Fritsch","sequence":"additional","affiliation":[{"name":"Pet Nutrition Center Hill's Pet Nutrition, Inc Topeka KS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Yerramilli","sequence":"additional","affiliation":[{"name":"IDEXX Laboratories, Inc Westbrook ME USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Obare","sequence":"additional","affiliation":[{"name":"IDEXX Laboratories, Inc Westbrook ME USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Yerramilli","sequence":"additional","affiliation":[{"name":"IDEXX Laboratories, Inc Westbrook ME USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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