{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:26:26Z","timestamp":1740126386477,"version":"3.37.3"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,5,11]],"date-time":"2017-05-11T00:00:00Z","timestamp":1494460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009751","name":"School of Veterinary Medicine, University of California, Davis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009751","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Findings in humans and rats indicate that hyperlipidaemia may be associated with enhanced endogenous oxalate (Ox) synthesis, which may be relevant for calcium oxalate (CaOx) urolith formation. Moreover, changes in lipid metabolism are proposed to negatively affect gut microbiota. This study aimed to investigate those potential interactions in hyperlipidaemic cats. Therefore, 10 normal control cats and seven lipoprotein lipase (<jats:styled-content style=\"fixed-case\">LPL<\/jats:styled-content>)\u2010deficient cats were fed a low\u2010fat diet for seven\u00a0weeks. During the last week of the study, cats were housed in metabolic cages to collect urine and faeces. Blood was taken on the last day of the study. The <jats:styled-content style=\"fixed-case\">LPL<\/jats:styled-content>\u2010deficient cats had significantly higher serum triglyceride concentrations than normal cats, while lactate dehydrogenase (LDH) activity was not different. Urinary relative supersaturation with CaOx, urinary Ox, calcium, and citrate excretions, and urine <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> did not differ between groups. Lower faecal acetic, propionic and total short\u2010chain fatty acid concentrations were observed in the <jats:styled-content style=\"fixed-case\">LPL<\/jats:styled-content>\u2010deficient cats. In conclusion, hyperlipidaemia does not appear to be a specific risk factor for CaOx urolith formation in cats. In contrast to results in rats, hyperlipidaemia was not accompanied by elevated serum <jats:styled-content style=\"fixed-case\">LDH<\/jats:styled-content> activity. As <jats:styled-content style=\"fixed-case\">LDH<\/jats:styled-content> can synthesise Ox from glycolate or other precursors, this might be one possible explanation for the similar urinary parameters in the <jats:styled-content style=\"fixed-case\">LPL<\/jats:styled-content>\u2010deficient and normal cats. Non\u2010diet\u2010induced hyperlipidaemia was not associated with marked changes in faecal microbial metabolites, suggesting no differences in the composition of the intestinal microbiota.<\/jats:p>","DOI":"10.1111\/jpn.12721","type":"journal-article","created":{"date-parts":[[2017,5,11]],"date-time":"2017-05-11T16:35:30Z","timestamp":1494520530000},"source":"Crossref","is-referenced-by-count":2,"title":["Impact of hyperlipidaemia on intermediary metabolism, faecal microbial metabolites and urinary characteristics of lipoprotein lipase deficient vs. normal cats"],"prefix":"10.1111","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7308-803X","authenticated-orcid":false,"given":"N.","family":"Pa\u00dflack","sequence":"first","affiliation":[{"name":"Institute of Animal Nutrition Department of Veterinary Medicine Freie Universit\u00e4t Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Zentek","sequence":"additional","affiliation":[{"name":"Institute of Animal Nutrition Department of Veterinary Medicine Freie Universit\u00e4t Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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