{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T19:28:14Z","timestamp":1784748494152,"version":"3.55.0"},"reference-count":57,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,6,12]],"date-time":"2017-06-12T00:00:00Z","timestamp":1497225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministry of Science and Higher Education, Poland","award":["N N311 543540"],"award-info":[{"award-number":["N N311 543540"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2018,2]]},"abstract":"Summary<\/jats:title>The varied bioavailability and different effects of organic forms of copper on the immune system of poultry have prompted the search for new feed additives based on copper compounds containing modified chelate complexes. The aim of the study was to determine the effect of inorganic and organic forms of copper on selected parameters of the cellular and humoral immune response in broiler chickens by determining the percentages of CD<\/jats:styled-content>3+<\/jats:sup>CD<\/jats:styled-content>4+<\/jats:sup>, CD<\/jats:styled-content>3+<\/jats:sup>CD<\/jats:styled-content>8+<\/jats:sup> and CD<\/jats:styled-content>25+<\/jats:sup> lymphocytes, cells with MHC<\/jats:styled-content> Class II<\/jats:styled-content> expression, and BU<\/jats:styled-content>\u20101+<\/jats:sup> cells, as well as the concentrations of SOD<\/jats:styled-content>, IL<\/jats:styled-content>\u20102, IL<\/jats:styled-content>\u201010 and TNF<\/jats:styled-content>\u2010\u03b1 in the peripheral blood. The experiments were conducted using 500 one\u2010day\u2010old Ross 308 roosters divided into five groups. Cu was added in inorganic form (CuSO<\/jats:styled-content>4<\/jats:sub>), in inorganic form with the addition of phytase (CuSO<\/jats:styled-content>4\u00a0+\u00a0F), in organic form in combination with glycine (Cu\u2010Gly) and in organic form in combination with glycine and a phytase supplement (Cu\u2010Gly+F). The results of the study indicate an increase in the percentage of CD<\/jats:styled-content>3+<\/jats:sup>CD<\/jats:styled-content>4+<\/jats:sup> and CD<\/jats:styled-content>3+<\/jats:sup>CD<\/jats:styled-content>8+<\/jats:sup> T lymphocytes, CD<\/jats:styled-content>25+<\/jats:sup> T cells, and cells expressing MHC<\/jats:styled-content> class II<\/jats:styled-content> molecules, and in the concentration of ceruloplasmin, activity of superoxide dismutase and the concentration of IL<\/jats:styled-content>\u20102 in the groups that received copper, particularly copper\u2010glycine chelates. Based on the study, we can conclude that supplementation of poultry feed with copper chelates activates mainly the Th1 cellular immune response and the response of peripheral blood T lymphocytes. Furthermore, it promotes secretion of cytokines, which are involved in potentiation and regulation of the immune response in birds.<\/jats:p>","DOI":"10.1111\/jpn.12750","type":"journal-article","created":{"date-parts":[[2017,6,12]],"date-time":"2017-06-12T05:03:36Z","timestamp":1497243816000},"source":"Crossref","is-referenced-by-count":20,"title":["The effect of feed supplementation with a copper\u2010glycine chelate and copper sulphate on selected humoral and cell\u2010mediated immune parameters, plasma superoxide dismutase activity, ceruloplasmin and cytokine concentration in broiler chickens"],"prefix":"10.1111","volume":"102","author":[{"given":"\u0141. S.","family":"Jarosz","sequence":"first","affiliation":[{"name":"Department of Epizootiology and Clinic of Infectious Diseases Faculty of Veterinary Medicine University of Life Sciences in Lublin Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Marek","sequence":"additional","affiliation":[{"name":"Department of Veterinary Prevention and Avian Diseases Faculty of Veterinary Medicine Institute of Biological Bases of Animal Diseases University of Life Sciences in Lublin Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Gr\u0105dzki","sequence":"additional","affiliation":[{"name":"Department of Epizootiology and Clinic of Infectious Diseases Faculty of Veterinary Medicine University of Life Sciences in Lublin Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kwiecie\u0144","sequence":"additional","affiliation":[{"name":"Department of Animal Nutrition Faculty of Biology and Animal Breeding Institute of Animal Nutrition and Bromatology University of Life Sciences in Lublin Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Kaczmarek","sequence":"additional","affiliation":[{"name":"Department and Clinic of Animal Internal Diseases Sub\u2010Department of Internal Diseases of Farm Animals and Horses Faculty of Veterinary Medicine University of Life Sciences in Lublin Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.3923\/javaa.2010.1510.1514","article-title":"Immunomodulatory effects of graded copper and zinc on SRBC titer and lymphoid organs in broiler chicks","volume":"9","author":"Arshami J.","year":"2010","journal-title":"Journal of Animal and Veterinary Advances"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(85)90381-9"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/japr\/16.3.448"},{"key":"e_1_2_7_5_1","first-page":"290","volume-title":"Practical book in Clinical Chemistry","author":"Bestujeva S. 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