{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T19:17:01Z","timestamp":1776799021910,"version":"3.51.2"},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,8,3]],"date-time":"2017-08-03T00:00:00Z","timestamp":1501718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"ECO-FCE (European Union's Seventh Framework Program for Research, Technological Development and Demonstration)","award":["KBBE.2012.1.3-03"],"award-info":[{"award-number":["KBBE.2012.1.3-03"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2018,4]]},"abstract":"Summary<\/jats:title>Lightweight (LW<\/jats:styled-content>) piglets from large litters display impaired growth performance compared with heavier littermates. This study investigated the growth performance and muscle development of early\u2010weaned LW<\/jats:styled-content> piglets (birthweight <1.2\u00a0kg) from large litters (17.3\u00a0\u00b1\u00a03.0 total born per litter), fed ad libitum a milk replacer supplemented with either l<\/jats:sc>\u2010carnitine (CAR<\/jats:styled-content>) or l<\/jats:sc>\u2010arginine (ARG<\/jats:styled-content>) from day 7 to day 28 of age. In total, 36 female and entire male Swiss Large White piglets, weaned on day 7 of age, were artificially reared in pairs in rescue decks. They were allocated to one of three dietary treatments: unsupplemented control (CON<\/jats:styled-content>), 0.48\u00a0g l<\/jats:sc>\u2010carnitine\u00b7piglet\u22121<\/jats:sup>\u00b7day\u22121<\/jats:sup> (CAR<\/jats:styled-content>) or 1.20\u00a0g l<\/jats:sc>\u2010arginine\u00b7kg body weight\u22121<\/jats:sup>\u00b7day\u22121<\/jats:sup> (ARG<\/jats:styled-content>). Milk replacer was prepared daily in a 1:4 powder\u2010to\u2010water ratio and fed ad libitum. Piglets were weighed at birth and on days 7, 14, 21 and 28. Feed intake was assessed daily. Piglets were euthanized on day 28. The entire semitendinosus<\/jats:italic> muscle (STM<\/jats:styled-content>) was collected, and organs were weighed. Subsequently, the STM<\/jats:styled-content> was divided into the light (STM<\/jats:styled-content>l<\/jats:sub>) and dark (STM<\/jats:styled-content>d<\/jats:sub>) portion, and contractile and metabolic traits were analysed by ATP<\/jats:styled-content> histochemistry, enzyme activities and gene expression. No differences in growth performance, organ and STM<\/jats:styled-content> weight and on contractile traits were found between groups. A tendency (p\u00a0<\/jats:italic><\u00a0<\/jats:italic>.10) for an elevated lipid oxidation enzyme activity in the STM<\/jats:styled-content>l<\/jats:sub> and STM<\/jats:styled-content>d<\/jats:sub> and greater (p\u00a0<\/jats:italic><\u00a0<\/jats:italic>.05) phosphorylation of the mammalian target of rapamycin pathway in the STM<\/jats:styled-content>l<\/jats:sub> of CAR<\/jats:styled-content> compared with CON<\/jats:styled-content> piglets was found. Despite these metabolic responses, the lack of effect of CAR<\/jats:styled-content> and ARG<\/jats:styled-content> supplementation on growth performance suggests that providing the milk replacer ad libitum in combination with added CAR<\/jats:styled-content> and ARG<\/jats:styled-content> is insufficient for eliciting faster growth of LW<\/jats:styled-content> piglets.<\/jats:p>","DOI":"10.1111\/jpn.12765","type":"journal-article","created":{"date-parts":[[2017,8,3]],"date-time":"2017-08-03T20:22:19Z","timestamp":1501791739000},"page":"440-451","source":"Crossref","is-referenced-by-count":9,"title":["Influence of l<\/scp>\u2010carnitine and l<\/scp>\u2010arginine on protein synthesis and maturation of the semitendinosus<\/i> muscle of lightweight piglets"],"prefix":"10.1111","volume":"102","author":[{"given":"J. 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