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Broilers were placed on a high\u2010nutrient diet for 41\u00a0days, and half were given orally <jats:styled-content style=\"fixed-case\">DEX<\/jats:styled-content>\u2010supplemented water at 20\u00a0mg\/L every other day from 19 to 41\u00a0days of age. <jats:styled-content style=\"fixed-case\">DEX<\/jats:styled-content> treatment downregulated superoxide dismutase activity as well as the <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression of CuZn\u2010superoxide dismutase and glutathione peroxidase with a decrease in <jats:styled-content style=\"fixed-case\">GSH<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">GSSG<\/jats:styled-content> ratio and an increase in malondialdehyde level in the liver of broilers. <jats:styled-content style=\"fixed-case\">DEX<\/jats:styled-content> treatment aggravated oxidative damage in the liver and, therefore, increased the sensitivity of broilers to ascites syndrome with higher mortality and reduced growth performance. Serum metabolomics analysis showed that <jats:styled-content style=\"fixed-case\">DEX<\/jats:styled-content> treatment significantly increased the levels of glucose, intermediates in protein metabolism (valine, proline, serine, threonine and urea) and lipid metabolism\u2010related products (palmitic acid, stearic acid and cholesterol) while decreasing the levels of \u03b2\u2010hydroxy butyric acid, succinic acid and malic acid, demonstrating that <jats:styled-content style=\"fixed-case\">DEX<\/jats:styled-content> treatment inhibited the Krebs cycle and the oxidation of fatty acids, and promoted the de novo synthesis of fatty acids as well as protein decomposition in the liver of broilers. Additionally, detection of metabolism\u2010related enzymes\u00a0revealed\u00a0that <jats:styled-content style=\"fixed-case\">DEX<\/jats:styled-content> treatment inhibited glycolysis and promoted glycogen decomposition. In summary, <jats:styled-content style=\"fixed-case\">DEX<\/jats:styled-content> treatment resulted in oxidative stress and glucose and lipid\u00a0metabolism disorders in the broilers.<\/jats:p>","DOI":"10.1111\/jpn.12823","type":"journal-article","created":{"date-parts":[[2017,11,3]],"date-time":"2017-11-03T10:18:38Z","timestamp":1509704318000},"source":"Crossref","is-referenced-by-count":34,"title":["Glucose and lipid metabolism disorders in the chickens with dexamethasone\u2010induced oxidative stress"],"prefix":"10.1111","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3795-6949","authenticated-orcid":false,"given":"Z.\u2010P.","family":"Lv","sequence":"first","affiliation":[{"name":"State Key Laboratory of Animal Nutrition College of Animal Science &amp; Technology China Agricultural University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.\u2010Z.","family":"Peng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Nutrition College of Animal Science &amp; Technology China Agricultural University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.\u2010B.","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Nutrition College of Animal Science &amp; Technology China Agricultural University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Fan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Nutrition College of Animal Science &amp; Technology China Agricultural University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Nutrition College of Animal Science &amp; Technology China Agricultural University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.\u2010M.","family":"Guo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Nutrition College of Animal Science &amp; Technology China Agricultural University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/00071660600611102"},{"key":"e_1_2_10_3_1","first-page":"221","article-title":"Effects of cold temperature and vitamin E supplementation on oxidative stress, Troponin\u2010T level, and other ascites\u2010related traits in broilers","volume":"72","author":"Aksit M.","year":"2008","journal-title":"Arch Geflugelkd"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.6.1640"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10540-005-2885-6"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpc.2009.04.005"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpc.2009.04.005"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000122852.22604.78"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps.0640809"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2001.52"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps.2008-00170"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2006.12.034"},{"key":"e_1_2_10_13_1","first-page":"665","article-title":"PPAR\u03b1, fibrates, lipid metabolism and inflammation","volume":"97","author":"Duval C.","year":"2004","journal-title":"Archives Des Maladies Du Coeur Et Des Vaisseaux"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/0007166031000085427"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1109083"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr0606326"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps.2009-00216"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078320"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.930744"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/00071660802337241"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2012-1341"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-190-42828"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-199520040-00002"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2010.107"},{"key":"e_1_2_10_25_1","doi-asserted-by":"crossref","first-page":"L283","DOI":"10.1152\/ajplung.2000.279.2.L283","article-title":"Early abnormalities of pulmonary vascular development in the Fawn\u2010Hooded rat raised at Denver's altitude. 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