{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T10:16:25Z","timestamp":1791022585924,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,8,17]],"date-time":"2018-08-17T00:00:00Z","timestamp":1534464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31730091"],"award-info":[{"award-number":["31730091"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2016M600630"],"award-info":[{"award-number":["2016M600630"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2018,12]]},"abstract":"Summary<\/jats:title>This study was conducted to investigate the effects of dietary amylose\/amylopectin ratio (DAR<\/jats:styled-content>) on serum and hepatic lipid content, luminal short\u2010chain fatty acid (SCFA<\/jats:styled-content>) concentrations, and the expression of host genes involved in fat and glucose metabolism in liver and mucosa in growing\u2010finishing pigs. Forty\u2010eight Duroc\u00a0\u00d7\u00a0Landrace\u00a0\u00d7\u00a0Large White pigs (49.8\u00a0\u00b1\u00a02.8\u00a0kg) were randomly allocated to low amylose\/amylopectin ratio (LR<\/jats:styled-content>) and high amylose\/amylopectin ratio (HR<\/jats:styled-content>) groups, each group consisting of six replicates (pen) with four pigs per pen. The DAR<\/jats:styled-content> was 12\/88 for LR<\/jats:styled-content> and 30\/70 for HR<\/jats:styled-content>. Experiment lasted for 67\u00a0days. Results showed that, compared with HR<\/jats:styled-content> group, ingestion of LR<\/jats:styled-content> significantly increased the liver total lipid and cholesterol concentration (p\u00a0<\/jats:italic><\u00a0.05) and decreased the serum LDL<\/jats:styled-content>\u2010C concentration (p\u00a0<\/jats:italic><\u00a0<\/jats:italic>.05). The concentration of propionate, butyrate and total SCFA<\/jats:styled-content>s in caecum digesta was significantly lower in LR<\/jats:styled-content> group than in HR<\/jats:styled-content> group (p\u00a0<\/jats:italic><\u00a0<\/jats:italic>.05). We observed a significant increase in glucose transporter 2 (GLUT<\/jats:styled-content>2), sodium\u2010dependent glucose transporter 1 (SGLT<\/jats:styled-content>1) gene expression in LR<\/jats:styled-content>\u2010fed pigs in the jejunum mucosa (p\u00a0<\/jats:italic><\u00a0<\/jats:italic>.01). A decrease in Na+\u2010coupled monocarboxylate transporter (SMCT<\/jats:styled-content>1) and free fatty acid receptor 3 (FFAR<\/jats:styled-content>3) expression was found in the ileum mucosa with LR<\/jats:styled-content> group (p\u00a0<\/jats:italic><\u00a0.05). Ingestion of LR<\/jats:styled-content> diet significantly decreased the hexokinase (p\u00a0<\/jats:italic><\u00a0.01) and tend to decrease the pyruvate kinase (p\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.050) activities in the liver. Meanwhile, the present results indicated that ingestion of LR<\/jats:styled-content> diet significantly increased the transcription of gluconeogenesis and lipogenic genes such as forkhead box O1 (FOXO<\/jats:styled-content>1), fatty acid synthetase3 (FAS<\/jats:styled-content>3) (p\u00a0<\/jats:italic><\u00a0.05). These findings demonstrated that high amylopectin has harmful effects on hepatic lipid deposit through the modulation of the liver Foxo1<\/jats:italic> signalling and should be avoided from one's diet.<\/jats:p>","DOI":"10.1111\/jpn.12884","type":"journal-article","created":{"date-parts":[[2018,8,18]],"date-time":"2018-08-18T04:34:57Z","timestamp":1534566897000},"page":"1657-1665","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["The effect of dietary amylose\/amylopectin ratio on serum and hepatic lipid content and its molecular mechanisms in growing\u2010finishing pigs"],"prefix":"10.1111","volume":"102","author":[{"given":"C.","family":"Yang","sequence":"first","affiliation":[{"name":"Institute of Animal Nutrition Sichuan Agricultural University Yaan Sichuan China"},{"name":"College of Life Sciences and Environment Hengyang Normal University Hengyang Hunan China"},{"name":"Animal Nutrition and Human Health Laboratory Hunan Normal University Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1963-9766","authenticated-orcid":false,"given":"J.","family":"He","sequence":"additional","affiliation":[{"name":"Institute of Animal Nutrition Sichuan Agricultural University Yaan Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Yu","sequence":"additional","affiliation":[{"name":"Institute of Animal Nutrition Sichuan Agricultural University Yaan Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Yu","sequence":"additional","affiliation":[{"name":"Institute of Animal Nutrition Sichuan Agricultural University Yaan Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X. B.","family":"Mao","sequence":"additional","affiliation":[{"name":"Institute of Animal Nutrition Sichuan Agricultural University Yaan Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8351-7421","authenticated-orcid":false,"given":"D. W.","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Animal Nutrition Sichuan Agricultural University Yaan Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. L.","family":"Yin","sequence":"additional","affiliation":[{"name":"Animal Nutrition and Human Health Laboratory Hunan Normal University Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114756"},{"key":"e_1_2_7_3_1","first-page":"25","article-title":"Starches, resistant starches, the gut microflora and human health","volume":"1","author":"Bird A. 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