{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T08:07:13Z","timestamp":1743581233998,"version":"3.37.3"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,5,9]],"date-time":"2018-05-09T00:00:00Z","timestamp":1525824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003121","name":"Ferdowsi University of Mashhad","doi-asserted-by":"publisher","award":["3\/22940"],"award-info":[{"award-number":["3\/22940"]}],"id":[{"id":"10.13039\/501100003121","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2018,8]]},"abstract":"Summary<\/jats:title>This study was conducted to investigate the efficacy of in ovo administration of aluminium hydroxide (AH<\/jats:styled-content>) and\/or mannan oligosaccharide (MOS<\/jats:styled-content>) adjuvants along with lentogenic VG<\/jats:styled-content>\/GA<\/jats:styled-content> strain\u2010Avinew to alleviate the embryonic pathogenicity of Newcastle disease virus. Six hundred and thirty fertilized Bovans eggs were divided into nine groups of 70 each incubated in a commercial hatchery and administered with eight types of in ovo injections in a factorial design of 2\u00a0\u00d7\u00a02\u00a0\u00d7\u00a02 including with\/without AH<\/jats:styled-content>, MOS<\/jats:styled-content> and Newcastle disease vaccine (NDV<\/jats:styled-content>), and one uninjected group on day 18 of incubation. Hatchability was higher in the eggs received MOS<\/jats:styled-content> and\/or AH<\/jats:styled-content> adjuvants plus NDV<\/jats:styled-content> compared those injected with NDV<\/jats:styled-content> alone which confirmed the attenuation of NDV<\/jats:styled-content>. However, the average daily feed intake and feed conversion ratio of pullets hatched from NDV<\/jats:styled-content>\u2010injected eggs were significantly reduced, but did not affect growth performance during 0\u201042 days of age. The performance of pullets hatched from eggs injected with AH<\/jats:styled-content>, MOS<\/jats:styled-content> or their mixture with NDV<\/jats:styled-content> was not significantly different during all growth periods. Pullets from MOS<\/jats:styled-content>\u00a0+\u00a0vaccine injected eggs had significantly higher antibody titres against NDV<\/jats:styled-content> compared to those hatched from either injected with saline or uninjected on d 28 (p<\/jats:italic>\u00a0<\u00a0.05). In addition, AH<\/jats:styled-content> plus vaccine and MOS<\/jats:styled-content> significantly improved total anti\u2010SRBC<\/jats:styled-content> and IgG respectively. Histological observation revealed that injection of MOS<\/jats:styled-content> adjuvant into eggs led to increase crypt depth, whereas AH<\/jats:styled-content> injection caused a reduction in villus surface area of jejunum in chicks on d 14 post\u2010hatch. It is concluded that in ovo MOS<\/jats:styled-content> injection as compared to AH<\/jats:styled-content> may be more effective to attenuate the embryonic pathogenicity of in ovo NDV<\/jats:styled-content> injection.<\/jats:p>","DOI":"10.1111\/jpn.12903","type":"journal-article","created":{"date-parts":[[2018,5,9]],"date-time":"2018-05-09T07:47:22Z","timestamp":1525852042000},"page":"977-985","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effect of adjuvants on in ovo vaccination against Newcastle disease on hatchability, performance and antibody titres in commercial pullets"],"prefix":"10.1111","volume":"102","author":[{"given":"P.","family":"Soleimani Roudi","sequence":"first","affiliation":[{"name":"Faculty of Agriculture Department of Animal Sciences Ferdowsi University of Mashhad Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9419-1175","authenticated-orcid":false,"given":"A.","family":"Golian","sequence":"additional","affiliation":[{"name":"Faculty of Agriculture Department of Animal Sciences Ferdowsi University of Mashhad Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Haghparast","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine Department of Pathobiology Ferdowsi University of Mashhad Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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