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A total of 320 1\u2010day\u2010old Arbor Acres broilers were randomly assigned into 5 dietary treatments and fed a basal diet supplemented with 0, 0.25, 0.5, 1 and 2\u00a0g\/kg <jats:styled-content style=\"fixed-case\">MP<\/jats:styled-content>al, respectively, for a 42\u2010day feeding trial. Treatments quadratically reduced feed\/gain ratio (F:G) during 1\u201321\u00a0days and linearly decreased average daily feed intake and F:G during 22\u201342\u00a0days, and linearly and quadratically decreased average daily feed intake and F:G during overall period (<jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05, 0.50\u00a0g\/kg treatment showed the lowest F:G). <jats:styled-content style=\"fixed-case\">MP<\/jats:styled-content>al supplementation increased the contents of 21\u2010day jejunal secretory immunoglobulin A (<jats:styled-content style=\"fixed-case\">SI<\/jats:styled-content>gA) quadratically, and 21\u2010day jejunal immunoglobulin G (IgG), immunoglobulin M (IgM) and 42\u2010day jejunal total superoxide dismutase (T\u2010<jats:styled-content style=\"fixed-case\">SOD<\/jats:styled-content>) activity linearly and quadratically (0.50\u00a0g\/kg treatment showed the highest immunoglobulin concentration), whereas linearly reduced 21\u2010day ileal <jats:styled-content style=\"fixed-case\">SI<\/jats:styled-content>gA level and 42\u2010day jejunal malondialdehyde (MDA) accumulation and serum diamine oxidase activity, and quadratically decreased 21\u2010day ileal MDA level (<jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05). The 42\u2010day jejunal <jats:styled-content style=\"fixed-case\">SI<\/jats:styled-content>gA, IgG and IgM concentrations, and T\u2010<jats:styled-content style=\"fixed-case\">SOD<\/jats:styled-content> activity in jejunum at 21\u00a0days and ileum at both 21\u00a0days and 42\u00a0days were quadratically increased with <jats:styled-content style=\"fixed-case\">MP<\/jats:styled-content>al administration (<jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05, 0.50\u00a0g\/kg treatment showed the highest T\u2010<jats:styled-content style=\"fixed-case\">SOD<\/jats:styled-content> activity). The mucin 2 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> abundances in 42\u2010day jejunum and 21\u2010day ileum were quadratically increased with <jats:styled-content style=\"fixed-case\">MP<\/jats:styled-content>al supplementation (<jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05). Treatments linearly increased 42\u2010day ileal zonula occludens\u20101, claudin\u20103 and jejunal claudin\u20103 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> level, whereas linearly and quadratically increased ileal claudin\u20102 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> level (<jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05). In conclusion, <jats:styled-content style=\"fixed-case\">MP<\/jats:styled-content>al supplementation exhibited beneficial effects on growth performance, intestinal immunity, antioxidant capacity and intestinal integrity and barrier function of broiler with its optimum dosage being 0.5\u00a0g\/kg.<\/jats:p>","DOI":"10.1111\/jpn.12974","type":"journal-article","created":{"date-parts":[[2018,8,16]],"date-time":"2018-08-16T12:06:07Z","timestamp":1534421167000},"page":"1574-1584","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Effects of different levels of modified palygorskite supplementation on the growth performance, immunity, oxidative status and intestinal integrity and barrier function of broilers"],"prefix":"10.1111","volume":"102","author":[{"given":"Yue","family":"Su","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology Nanjing Agricultural University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yueping","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Nanjing Agricultural University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingjie","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Nanjing Agricultural University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiao","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Nanjing Agricultural University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuru","family":"Kang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Clay Mineral Applied Research of Gansu Province Center of Eco\u2010material and Green Chemistry Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences  Lanzhou China"},{"name":"R&amp;D Center of Xuyi Palygorskite Applied Technology Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences  Xuyi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenbo","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Clay Mineral Applied Research of Gansu Province Center of Eco\u2010material and Green Chemistry Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences  Lanzhou China"},{"name":"R&amp;D Center of Xuyi Palygorskite Applied Technology Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences  Xuyi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aiqin","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Clay Mineral Applied Research of Gansu Province Center of Eco\u2010material and Green Chemistry Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences  Lanzhou China"},{"name":"R&amp;D Center of Xuyi Palygorskite Applied Technology Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences  Xuyi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Wen","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Nanjing Agricultural University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7844-542X","authenticated-orcid":false,"given":"Yanmin","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Nanjing Agricultural University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,8,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2003.12.011"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.desal.2006.10.024"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S1357-2725(98)00028-4","article-title":"The MUC2 gene product: A human intestinal mucin","volume":"30","author":"Allen A.","year":"1998","journal-title":"International Journal of Biochemistry and Cell Biology"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps.0600124"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/japr\/15.2.198"},{"key":"e_1_2_7_7_1","volume-title":"Handbook of Clay Science. 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