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A total of 20 healthy weaned piglets (Duroc\u00d7 [Large White\u00d7Landrace]), weaned at 21\u00a0days of age with an average body weight (<jats:styled-content style=\"fixed-case\">BW<\/jats:styled-content>) of 6.52\u00a0\u00b1\u00a00.23\u00a0kg, were randomly assigned to receive either a corn\u2010soybean meal basal diet (<jats:styled-content style=\"fixed-case\">CTR<\/jats:styled-content>) or a basal diet supplemented with 50\u00a0mg\/kg<jats:styled-content style=\"fixed-case\">SAG<\/jats:styled-content>(<jats:styled-content style=\"fixed-case\">SAG<\/jats:styled-content>). During the 21\u2010days trial, we collected and analysed intestinal tissues and the luminal digesta for their morphology and populations of gut microbiota, as well as for measuring the concentrations of short\u2010chain fatty acids (<jats:styled-content style=\"fixed-case\">SCFA<\/jats:styled-content>s) and ammonia. Compared with the<jats:styled-content style=\"fixed-case\">CTR<\/jats:styled-content>group, supplementation with<jats:styled-content style=\"fixed-case\">SAG<\/jats:styled-content>improved average daily gains (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.011) and average daily feed intake (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.037). Piglets fed the<jats:styled-content style=\"fixed-case\">SAG<\/jats:styled-content>diet had an average lower value for crypt depth of the jejunum (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.011) and greater values for villus height in the ileum (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.015) and ratios of villus height to crypt depth in the jejunum (<jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.01) and in the ileum (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.027) than did animals receiving the<jats:styled-content style=\"fixed-case\">CTR<\/jats:styled-content>diet. The addition of<jats:styled-content style=\"fixed-case\">SAG<\/jats:styled-content>increased the amounts of<jats:italic>Lactobacillus<\/jats:italic>in the ileum (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.033) and caecum (<jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.01), and tended to increase the amounts of<jats:italic>Bifidobacterium<\/jats:italic>(<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.058) in the caecum, while decreasing the amounts of<jats:italic>Escherichia coli<\/jats:italic>(<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.046) and<jats:italic>Salmonella<\/jats:italic>spp. (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.035) in the ileum, as well as<jats:italic>Salmonella<\/jats:italic>spp. (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.029) in the caecum. Dietary supplementation with<jats:styled-content style=\"fixed-case\">SAG<\/jats:styled-content>enhanced (<jats:italic>p\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05) the concentrations of acetate, propionate, butyrate and total<jats:styled-content style=\"fixed-case\">SCFA<\/jats:styled-content>s, and also tended to increase the level of valerate (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.055 and<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.052) in the ileal and caecal contents when compared with the<jats:styled-content style=\"fixed-case\">CTR<\/jats:styled-content>group. Concentrations of ammonia also declined in the caecal (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.037) and ileal (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.046) digesta in response to<jats:styled-content style=\"fixed-case\">SAG<\/jats:styled-content>. These results indicate that feeding early\u2010weaned piglets a<jats:styled-content style=\"fixed-case\">SAG<\/jats:styled-content>\u2010supplemented diet can potentially improve their growth performance and intestinal morphology, and can modify the intestinal luminal environment in a beneficial manner.<\/jats:p>","DOI":"10.1111\/jpn.12976","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T15:21:37Z","timestamp":1534951297000},"page":"1666-1674","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Effects of natural dietary supplementation with<i>Macleaya cordata<\/i>extract containing sanguinarine on growth performance and gut health of early\u2010weaned piglets"],"prefix":"10.1111","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4474-6803","authenticated-orcid":false,"given":"Jiashun","family":"Chen","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology Hunan Agricultural University Changsha Hunan China"},{"name":"Key Laboratory of Agro\u2010ecological Processes in Subtropical Region Hunan Provincial Engineering Research Center of Healthy Livestock Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South\u2010Central Ministry of Agriculture Institute of Subtropical Agriculture Chinese Academy of Sciences Changsha Hunan China"},{"name":"Hunan Collaborative Innovation Center for Utilization of Botanical Functional Ingredients and Hunan Collaborative Innovation Center of Animal Production Safety Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoju","family":"Kang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Hunan Agricultural University Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurong","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Hunan Agricultural University Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Yao","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Hunan Agricultural University Changsha Hunan China"},{"name":"Key Laboratory of Agro\u2010ecological Processes in Subtropical Region Hunan Provincial Engineering Research Center of Healthy Livestock Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South\u2010Central Ministry of Agriculture Institute of Subtropical Agriculture Chinese Academy of Sciences Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxing","family":"Fu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Hunan Agricultural University Changsha Hunan China"},{"name":"Hunan Collaborative Innovation Center for Utilization of Botanical Functional Ingredients and Hunan Collaborative Innovation Center of Animal Production Safety Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature18849"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpn.12528"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.livsci.2010.06.086"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps.2013-03366"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.48.30129"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anifeedsci.2016.06.013"},{"key":"e_1_2_8_8_1","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1093\/jn\/123.2.234","article-title":"Metabolic characteristics of pig colonocytes after adaptation to a high fiber diet","volume":"123","author":"Darcy\u2010Vrillon B.","year":"1993","journal-title":"The Journal of Nutrition"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756369609036530"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2016.06.003"},{"key":"e_1_2_8_11_1","first-page":"30","article-title":"The role of gut microbiota in the health and disease of pigs","volume":"6","author":"Fouhse J. 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