{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T02:16:05Z","timestamp":1770776165260,"version":"3.50.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,8,9]],"date-time":"2018-08-09T00:00:00Z","timestamp":1533772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A total of 224 weaned pigs (DanBred sows x <jats:styled-content style=\"fixed-case\">PIC<\/jats:styled-content> 337 sires) with an average body weight (<jats:styled-content style=\"fixed-case\">BW<\/jats:styled-content>) of 6.37\u00a0\u00b1\u00a00.34\u00a0kg (21\u00a0days of age) were used to evaluate how different levels of benzoic acid fed to weaning pigs orally inoculated with <jats:italic>Escherichia coli<\/jats:italic> (K88<jats:sup>+<\/jats:sup>) affected the nursing and grow\u2010finishing performance, the physicochemical properties of the intestine, the volatile fatty acid concentration in the caecum and the incidence of diarrhoea. Pigs were randomly allocated in an experimental design of randomized blocks in a 4\u00a0\u00d7\u00a02 factorial design, and they were administered four levels of benzoic acid (0.00%, 0.25%, 0.50% and 0.75%) and inoculated (or not) in two consecutive days with 1\u00a0ml solution containing 10<jats:sup>6<\/jats:sup> <jats:styled-content style=\"fixed-case\">CFU<\/jats:styled-content>\/ml of <jats:italic>E.\u00a0coli<\/jats:italic> (K88<jats:sup>+<\/jats:sup>). Seven replicates (pens) per treatment were used, and four animals were kept per pen. Supplementation with 0.75% benzoic acid promoted better performance (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) in the nursery phase as well as in the subsequent phases until slaughter, and it decreased the incidence of diarrhoea in piglets (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). In the piglets fed the benzoic acid diet, the villus height in the jejunum and ileum was greater until 42 days of life (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05), the crypt depth was decreased in the caecum (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05), and the butyric acid concentration was increased in the caecal content tendencially (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0708). In conclusion, supplementation with 0.75% benzoic acid has a positive effect on piglets by reducing diarrhoea, improving intestinal health and promoting the performance from weaning to finishing. Thus, benzoic acid can be considered a potential alternative that can replace growth\u2010promoting antibiotics.<\/jats:p>","DOI":"10.1111\/jpn.12977","type":"journal-article","created":{"date-parts":[[2018,8,10]],"date-time":"2018-08-10T04:25:13Z","timestamp":1533875113000},"page":"1675-1685","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Benzoic acid in nursery diets increases the performance from weaning to finishing by reducing diarrhoea and improving the intestinal morphology of piglets inoculated with <i>Escherichia coli<\/i> K88<sup>+<\/sup>"],"prefix":"10.1111","volume":"102","author":[{"given":"Hebert","family":"Silveira","sequence":"first","affiliation":[{"name":"Department of Animal Science Federal University of Lavras (UFLA)  Lavras Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leticia Gomes de Morais","family":"Amaral","sequence":"additional","affiliation":[{"name":"Department of Animal Science Federal University of Lavras (UFLA)  Lavras Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3244-7184","authenticated-orcid":false,"given":"Cesar Augusto Pospissil","family":"Garbossa","sequence":"additional","affiliation":[{"name":"Department of Animal Nutrition and Production School of Veterinary Medicine and Animal Sciences University of S\u00e3o Paulo (USP)  Pirassununga Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leticia Mendon\u00e7a","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Department of Animal Science Federal University of Lavras (UFLA)  Lavras Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia Cassimira da","family":"Silva","sequence":"additional","affiliation":[{"name":"DSM Nutritional Products Animal Nutrition and Health  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5363-6991","authenticated-orcid":false,"given":"V\u00ednicius de Souza","family":"Cantarelli","sequence":"additional","affiliation":[{"name":"Department of Animal Science Federal University of Lavras (UFLA)  Lavras Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,8,9]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"447","article-title":"\u00c1cido benzoico y un producto basado en especies de Bacillus para proteger la productividad de los lechones y al ambiente","volume":"4","author":"Alvarado A. 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