{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:13:30Z","timestamp":1787015610229,"version":"build-2736575974"},"reference-count":64,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T00:00:00Z","timestamp":1546905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The aim of the study was to evaluate the effects of a diet containing different levels of Cu in two different chemical forms (carbonate and nanoparticles) on redox reactions and epigenetic changes in a rat model. For 4\u00a0weeks, five experimental groups (eight rats in each) were fed diets with two dosages of added Cu (standard\u20146.5\u00a0mg\/kg or half of the standard dosage\u20143.25\u00a0mg\/kg, and as a negative control no additional Cu in the mineral mixture) in two forms (standard\u2014CuCO\n                    <jats:sub>3<\/jats:sub>\n                    and copper nanoparticles). Addition of Cu nanoparticles resulted in higher Cp (ceruloplasmin) activity and LOOH (lipid peroxides) and MDA (malondialdehyde) content, as well as decrease the CAT (catalase) activity and level of PC (protein carbonyl), 3\u2010NT (3\u2010nitrotyrosine), 8\u2010OHdG (8\u2010hydroxydeoxyguanosine), GSH\u00a0+\u00a0GSSG (total glutathione) and DNA methylation. Reducing the dose of copper resulted in a decrease in the level of LOOH and GSH\u00a0+\u00a0GSSG as well as CAT activity, but increased the level of PC and methylated DNA. Based on these evidence, we concluded that addition of copper nanoparticles in the diet reduces protein oxidation and nitration as well as DNA oxidation and methylation. Lowering the level of Cu in the diet increases the oxidation of proteins and DNA methylation.\n                  <\/jats:p>","DOI":"10.1111\/jpn.13025","type":"journal-article","created":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T23:34:36Z","timestamp":1546990476000},"page":"675-686","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["The effect of copper nanoparticles and copper (II) salt on redox reactions and epigenetic changes in a rat model"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4393-4092","authenticated-orcid":false,"given":"Katarzyna","family":"Ognik","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Toxicology, Faculty of Biology, Animal Sciences and Bioeconomy University of Life Science in Lublin Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0437-4766","authenticated-orcid":false,"given":"Ewelina","family":"Cholewi\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Toxicology, Faculty of Biology, Animal Sciences and Bioeconomy University of Life Science in Lublin Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0068-5970","authenticated-orcid":false,"given":"Jerzy","family":"Ju\u015bkiewicz","sequence":"additional","affiliation":[{"name":"Division of Food Science Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences Olsztyn Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0640-7552","authenticated-orcid":false,"given":"Zenon","family":"Zdu\u0144czyk","sequence":"additional","affiliation":[{"name":"Division of Food Science Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences Olsztyn Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3742-3715","authenticated-orcid":false,"given":"Krzysztof","family":"Tutaj","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Toxicology, Faculty of Biology, Animal Sciences and Bioeconomy University of Life Science in Lublin Lublin Poland"},{"name":"Faculty of Medicine, Centre for Innovative Research in Medical and Natural Sciences University of Rzesz\u00f3w Rzesz\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0871-2427","authenticated-orcid":false,"given":"Rados\u0142aw","family":"Szl\u0105zak","sequence":"additional","affiliation":[{"name":"Department of Metrology and Modelling of Agrophysical Processes Bohdan Dobrza\u0144ski Institute of Agrophysics of the Polish Academy of Sciences Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114507239960"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2001.tb02273.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2005.08.020"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0531-5565(01)00133-4"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2174\/2212796809666150227223857"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2016.02.006"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0963-9969(01)00187-9"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/09553002.2013.877176"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2017.02.007"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2005.10.003"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2018.03.017"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0197083"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2010.00271.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(03)00003-2"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mas.20006"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/00958970802474755"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2095-3119(13)60389-5"},{"key":"e_1_2_8_19_1","doi-asserted-by":"crossref","first-page":"404","DOI":"10.21608\/besps.2014.34831","article-title":"Protective effect of multivitamin complex on copper oxide nanoparticles (nanoCuO) induced toxicity in rats","volume":"34","author":"Elhussainy E. 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