{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T03:29:32Z","timestamp":1766719772190,"version":"3.37.3"},"reference-count":57,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,12,28]],"date-time":"2018-12-28T00:00:00Z","timestamp":1545955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31501927"],"award-info":[{"award-number":["31501927"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was conducted to investigate the effect of heat stress on the hair follicle population and related signalling pathways in rex rabbits. Forty\u2010eight rabbits were randomly divided into two groups: one group in a high ambient environment (32\u00a0\u00b1\u00a02\u00b0C, heat stress) and the other group with normal temperature (20\u00a0\u00b1\u00a02\u00b0C, control). The results show that heat stress decreased the body weight gain and feed conversion rate, rabbit hair length and hair follicle density (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Besides, heat stress suppressed the gene expression of noggin, insulin\u2010like growth factor 1 (IGF\u20101) and IGF\u20101 receptor and protein expression of phosphorylated mechanistic target of rapamycin (mTOR) in rabbit skin (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05), while stimulated significantly the gene expression of bone morphogenetic protein 2 (BMP2) and BMP4 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Heat exposure did not alter significantly the gene expression of alkaline phosphatase, versican and hepatocyte growth factor compared with the control (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05). In conclusion, noggin\u2010BMP, IGF\u20101 and mTOR signalling pathways may be associated with the process of heat stress\u2010repressing hair follicle development.<\/jats:p>","DOI":"10.1111\/jpn.13044","type":"journal-article","created":{"date-parts":[[2018,12,29]],"date-time":"2018-12-29T06:18:55Z","timestamp":1546064335000},"page":"501-508","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Heat stress decreased hair follicle population in rex rabbits"],"prefix":"10.1111","volume":"103","author":[{"given":"Haitao","family":"Sun","sequence":"first","affiliation":[{"name":"Shangdong Academy of Agricultural Sciences, Shandong Key Lab of Animal Disease Control and Breeding Institute of Animal Science and Veterinary Medicine Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shangdong Academy of Agricultural Sciences, Shandong Key Lab of Animal Disease Control and Breeding Institute of Animal Science and Veterinary Medicine Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9925-5721","authenticated-orcid":false,"given":"Liya","family":"Bai","sequence":"additional","affiliation":[{"name":"Shangdong Academy of Agricultural Sciences, Shandong Key Lab of Animal Disease Control and Breeding Institute of Animal Science and Veterinary Medicine Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuding","family":"Wang","sequence":"additional","affiliation":[{"name":"Shangdong Academy of Agricultural Sciences, Shandong Key Lab of Animal Disease Control and Breeding Institute of Animal Science and Veterinary Medicine Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Yang","sequence":"additional","affiliation":[{"name":"Shangdong Academy of Agricultural Sciences, Shandong Key Lab of 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