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In a 2\u00a0\u00d7\u00a02 factorial arrangement, pigs were fed either a corn\u2013soybean meal (CSB) or corn\u2013field pea (CFP) diet with either low [\u2010] (4.4\u00a0g Ca\/kg; 4.2\u00a0g total P\/kg) or high [+] (8.3\u00a0g Ca\/kg; 7.5\u00a0g total P\/kg; supplemented with monocalcium phosphate) CaP content for a period of 9\u00a0weeks. In week 8, blood samples were taken, and at the end of the trial, all pigs were euthanized to collect digesta and mesenteric lymphoid tissue. Apparent total tract digestibility (ATTD) of P was greater (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) for pigs fed the CaP+\u00a0and CFP diets than CaP\u2010 and CSB diets. The <jats:italic>myo<\/jats:italic>\u2010inositol 1,2,3,4,5,6\u2010hexakis (dihydrogen phosphate) (InsP<jats:sub>6<\/jats:sub>) concentration in jejunal digesta was higher (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) for CaP+\u00a0than in CaP\u2010 fed pigs. In addition, caecal and faecal InsP<jats:sub>5 <\/jats:sub>isomer concentration were greater (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) for CSB than CFP diets. In the caecum, gene copy numbers of saccharolytic bacteria, such as <jats:italic>Eubacterium rectale<\/jats:italic> and <jats:italic>Roseburia<\/jats:italic> spp., as well as SCFA concentration were higher (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) for CaP+\u00a0than CaP\u2010 diets. In particular, innate immune cell numbers, such as natural killer cells, dendritic cells, monocytes and neutrophils, were greater (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) for CaP+\u00a0than CaP\u2010 fed pigs. Diets high in CaP resulted in higher abundance of potential beneficial bacteria and might promote the first line of defence enhancing the activation of the cellular adaptive immune response, thereby possibly decreasing the risk for intestinal disturbances. These results strongly suggest that both, CaP supply and dietary ingredients differing in fermentability, may beneficially affect gut health through increase in SCFA\u2010producing bacteria and\/or bacteria with anti\u2010inflammatory properties.<\/jats:p>","DOI":"10.1111\/jpn.13088","type":"journal-article","created":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T16:32:25Z","timestamp":1554136345000},"page":"1185-1197","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Phytate degradation, intestinal microbiota, microbial metabolites and immune values are changed in growing pigs fed diets with varying calcium\u2013phosphorus concentration and fermentable substrates"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5110-8797","authenticated-orcid":false,"given":"Charlotte Maria Elisabeth","family":"Heyer","sequence":"first","affiliation":[{"name":"Institute of Animal Science University of Hohenheim Stuttgart Germany"},{"name":"Department of Agricultural, Food and Nutritional Science University of Alberta Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonja","family":"Schmucker","sequence":"additional","affiliation":[{"name":"Institute of Animal Science University of Hohenheim Stuttgart Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Burbach","sequence":"additional","affiliation":[{"name":"Institute of Animal Science University of Hohenheim Stuttgart Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Weiss","sequence":"additional","affiliation":[{"name":"Institute of Animal Science University of Hohenheim Stuttgart Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meike","family":"Eklund","sequence":"additional","affiliation":[{"name":"Institute of Animal Science University of Hohenheim Stuttgart Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Aumiller","sequence":"additional","affiliation":[{"name":"Institute of Animal Science University of Hohenheim Stuttgart Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filippo","family":"Capezzone","sequence":"additional","affiliation":[{"name":"Institute of Crop Science University of Hohenheim Stuttgart Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Steuber","sequence":"additional","affiliation":[{"name":"Institute of Microbiology University of Hohenheim Stuttgart Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3156-7889","authenticated-orcid":false,"given":"Markus","family":"Rodehutscord","sequence":"additional","affiliation":[{"name":"Institute of Animal Science University of Hohenheim Stuttgart Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludwig Eduard","family":"Hoelzle","sequence":"additional","affiliation":[{"name":"Institute of Animal Science University of Hohenheim Stuttgart Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7690-8539","authenticated-orcid":false,"given":"Jana","family":"Seifert","sequence":"additional","affiliation":[{"name":"Institute of Animal Science University of Hohenheim Stuttgart Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rainer","family":"Mosenthin","sequence":"additional","affiliation":[{"name":"Institute of Animal Science University of Hohenheim Stuttgart Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volker","family":"Stefanski","sequence":"additional","affiliation":[{"name":"Institute of Animal Science University of Hohenheim Stuttgart Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,4]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"903","volume-title":"Swine nutrition","author":"Adeola O.","year":"2001"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19910083"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19930147"},{"key":"e_1_2_7_5_1","first-page":"109","volume-title":"Sustainable swine nutrition","author":"Bach Knudsen K. 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