{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:16:11Z","timestamp":1787242571600,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T00:00:00Z","timestamp":1555891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Special Fund of Hunan Co-Innovation Center of Animal Production Safety"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study was conducted to investigate the effects of dietary supplementation with montmorillonite (MMT) on performance, intestinal endotoxin concentration, gut mucosal oxidation status, intestinal morphology and permeability, and immunological barrier function of laying hens during late production. Four hundred and eighty 75\u2010week\u2010old laying hens (Lohmann Brown) were randomly assigned to five treatments with eight replicates per treatment and 12 hens in each replicate. The hens were fed the basal diet supplemented with 0 (control), 0.3, 0.6, 0.9, or 1.2\u00a0g MMT\/kg for 70\u00a0days. Compared with the control, supplemented with 0.9\u00a0g MMT\/kg increased egg mass significantly (\n                    <jats:italic>p\u00a0&lt;\u00a0<\/jats:italic>\n                    0.05) during weeks 1\u20135 of the experiment. Supplemented with 0.6 and 0.9\u00a0g MMT\/kg also increased the endotoxin concentration in the ileal digesta (\n                    <jats:italic>p\u00a0&lt;\u00a0<\/jats:italic>\n                    0.05), but decreased the MDA concentration in the ileum significantly (\n                    <jats:italic>p\u00a0&lt;\u00a0<\/jats:italic>\n                    0.05). The T\u2010AOC in the jejunum of the group fed 0.3\u00a0g MMT\/kg was significantly increased (\n                    <jats:italic>p\u00a0&lt;\u00a0<\/jats:italic>\n                    0.05). Compared with the control, the villus height:crypt depth of ileum from the groups fed 0.6, 0.9, and 1.2\u00a0g MMT\/kg increased significantly (\n                    <jats:italic>p\u00a0&lt;\u00a0<\/jats:italic>\n                    0.05). The sIgA concentration of jejunum in the groups fed 0.6 and 0.9\u00a0g MMT\/kg was higher (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.05) than the control. The MMT supplementation linearly increased (\n                    <jats:italic>p\u00a0&lt;\u00a0<\/jats:italic>\n                    0.05) the mRNA expression of claudin\u20101 and claudin\u20105 in the jejunum. Dietary MMT supplementation down\u2010regulated the mRNA expression of NF\u2010\u03baB P65 and TNF\u2010\u03b1 in the jejunum in a linear and quadratic manner (\n                    <jats:italic>p\u00a0&lt;\u00a0<\/jats:italic>\n                    0.05). The IL\u20101\u03b2 mRNA expression of jejunum in the group fed 0.6\u00a0g MMT\/kg was lower (\n                    <jats:italic>p\u00a0&lt;\u00a0<\/jats:italic>\n                    0.05) than the control. In conclusion, dietary supplementation with MMT may improve the gut barrier functions and suggests that 0.9\u00a0g\/kg of MMT in diets may be the optimal supplemental level for laying hens in late production.\n                  <\/jats:p>","DOI":"10.1111\/jpn.13094","type":"journal-article","created":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T06:28:50Z","timestamp":1555914530000},"page":"1081-1089","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Montmorillonite improved the intestinal mucosal barrier functions of laying hens in late production"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6186-3019","authenticated-orcid":false,"given":"Ji Fa","family":"Chen","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology Hunan Agricultural University Changsha China"},{"name":"Hunan Co\u2010Innovation Center of Animal Production Safety Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6254-6322","authenticated-orcid":false,"given":"Xu","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Hunan Agricultural University Changsha China"},{"name":"Hunan Co\u2010Innovation Center of Animal Production Safety Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyong","family":"Qu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Hunan Agricultural University Changsha China"},{"name":"Hunan Co\u2010Innovation Center of Animal Production Safety Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songchang","family":"Guo","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Hunan Agricultural University Changsha China"},{"name":"Hunan Co\u2010Innovation Center of Animal Production Safety Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps\/pey101"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00544074"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2741\/3413"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2015.12.016"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins9020060"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anifeedsci.2016.08.012"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2013.10.005"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40104-018-0275-8"},{"key":"e_1_2_7_10_1","first-page":"3183","article-title":"Effects of mycotoxin adsorbents on performance, egg trace element contents, serum antioxidant and biochemical indices of 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