{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T03:37:43Z","timestamp":1789875463570,"version":"4.0.1"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T00:00:00Z","timestamp":1557100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The National Basic Research Program of China","award":["2013CB127306"],"award-info":[{"award-number":["2013CB127306"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Physiology Nutrition"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hydroxyapatite, a mineral form of calcium (Ca) and phosphorus (P) that gives bones their rigidity, is the major and essential component of bones and teeth in the human and animal body. A suitable ratio of Ca and P is vital for bone growth. The aim of this study was to explore the effects of dietary calcium to available phosphorus ratios (Ca\/AP) on bone metabolism and osteoclast activity of the osteoprotegerin (OPG)\/receptor activator of nuclear factor kappa B ligand (RANKL) signalling pathway in piglets. At days 15 and 29, the piglets were assessed for growth performance, blood indicators, cytokines and the OPG\/RANK\/RANKL signalling pathway. Our results showed that piglets fed a dietary Ca\/AP ratio of 2:1 increases growth performance and regulates blood indicators and cytokines (parathyroid hormone (PTH), calcitonin (CT), vitamin D<jats:sub>3 <\/jats:sub>(VD<jats:sub>3<\/jats:sub>)<jats:sub>, <\/jats:sub>insulin\u2010like growth factor\u20101 (IGF\u20101), transforming growth factor\u2010\u03b2 (TGF\u2010\u03b2), interleukin\u20101 (IL\u20101), interleukin\u20106 (IL\u20106), carboxyterminal propeptide of type I procollagen (PICP), tartrate\u2010resistant acid phosphatase (TRACP), alkaline phosphatase (ALP) and osteocalcin (OCN) content). We also demonstrated that this ratio affects hormone secretion and further bone metabolism through the OPG\/RANK\/RANKL signalling pathway of osteoclasts. These results indicate that a suitable dietary Ca\/AP ratio is vital for bone growth and reduce the incidence of bone diseases such as osteoporosis, providing a practical basis for the raising of piglets.<\/jats:p>","DOI":"10.1111\/jpn.13115","type":"journal-article","created":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T05:11:42Z","timestamp":1557205902000},"page":"1224-1232","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Effects of dietary calcium to available phosphorus ratios on bone metabolism and osteoclast activity of the OPG \/RANK\/RANKL signalling pathway in piglets"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6512-2725","authenticated-orcid":false,"given":"Lei","family":"Zhao","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology Jilin Agriculture University Changchun China"},{"name":"Ministry of education laboratory of animal production and quality security Jilin Agricultural University Changchun China"},{"name":"Jilin Provincial Key Laboratory of Animal Nutrition and Feed Science Jilin Agricultural University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9331-863X","authenticated-orcid":false,"given":"Muyang","family":"Li","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Jilin Agriculture University Changchun China"},{"name":"Ministry of education laboratory of animal production and quality security Jilin Agricultural University Changchun China"},{"name":"Jilin Provincial Key Laboratory of Animal Nutrition and Feed Science Jilin Agricultural University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5408-9755","authenticated-orcid":false,"given":"Hui","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Jilin Agriculture University Changchun China"},{"name":"Ministry of education laboratory of animal production and quality security Jilin Agricultural University Changchun China"},{"name":"Jilin Provincial Key Laboratory of Animal Nutrition and Feed Science Jilin Agricultural University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-001-0644-8"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1997.2431019.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2013.10.008"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2013.1149"},{"key":"e_1_2_7_6_1","first-page":"248","article-title":"Observation of the effect of calcitonin on osteoclasts","volume":"8","author":"Gao J. 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